An administrative supplement is requested for a grant that has two broad research themes: the roles of anion transporter SLC26A6 and related transporters in proximal tubule NaCl transport; and the roles of SLC26A6 and related transporters in mediating intestinal transport of oxalate, a prime determinant of steady state urinary oxalate excretion.
A major portion of the supplemental funds will be used to purchase equipment that will enhance ability to pursue goals on both of these themes of the parent grant. Specifically, a fluorescence imaging system will be purchased to greatly improve the technical capability to conduct studies involving quantitative immunoblotting. In addition, a new thermal cycler will be purchased to improve technical capability to perform PCR for diverse project goals.
Another major portion of the supplemental funds will be used to provide two years of salary support for a postdoctoral fellow to conduct studies on the mechanisms of intestinal oxalate absorption, one of the important project goals of the parent grant.
These supplemental funds will be used within a two-year period and will serve to both accelerate the rate of progress and enhance the quality of research conducted on the goals of the parent grant.