H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.
The Moffitt Cancer Center requests an administrative supplement to its Cancer Center Support Grant (5 P30 CA076292-11) to expand the support for the technological platforms offered by the Microarray Core Facility in the area of the genomic evaluation of cancer, a CCSG funded Shared Resource. Genomic evaluation includes the genome wide analysis of genetic and epigenetic changes in cancer cells, the role of copy number changes in tumors and the surrounding normal tissue on the development of tumors, and the analysis of single nucleotide polymorphisms in populations and individuals that relate to cancer development and response to treatment. Based on increasing demands and usage, the Center wishes to hire a Staff Scientist with advanced expertise in the processing and analysis of microarray samples that probe the cancer genome. To support the analysis and documentation of intermediate steps in the processing of samples for microarray analysis, the institution requests to purchase a Bioanalyzer, a microfluidics based instrument for detailed analysis of nucleic acid samples.
The Microarray Core Facility is a shared resource for services, materials and equipment required for performing large-scale gene expression studies utilizing oligonucleotide-based microarrays. Utilizing highly trained staff and equipment, the Core also processes samples for experiments utilizing the arrays and supporting bioinformatics available from the Affymetrix Corporation.
This supplement is highly relevant to the American Recovery and Reinvestment Act of 2009. First and foremost, it will enable the Core to hire a high level staff scientist, which will stimulate the local economy. Second, adding additional expertise and equipment to the Microarray Core will immediately support investigators and accelerate the pace of research through the addition of new technology. Microarray services, including data analysis, are critical to numerous NCI funded projects and the ability of our investigators to perform their research.