HARVARD COLLEGE, PRESIDENT & FELLOWS OF
Under this CAREER award the PI will develop and test general theories of cytoskeletal organization, and thereby obtain an understanding of the architecture and dynamics of the metaphase spindle. The project will use fluorescence and polarized light microscopy, in conjunction with magnetic tweezers and biochemical approaches, to study the spindle's internal fluctuations, structure, and response to perturbations. The results of these quantitative experiments will be compared with predictions from coarse-grained models of cytoskeletal behavior. The educational component of the project will bridge the gap between physical scientists and biologists. This will be accomplished by promoting interdisciplinary research, developing an undergraduate course to teach cell biology to physicists and engineers, the creation of an interdisciplinary, graduate level, project based laboratory class, and will incorporate basic quantitative methods into biology education at the high school level.
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| AWARD OVERVIEW |
| Award Number |
0847188 |
Funding Agency |
National Science Foundation |
| Total Award Amount |
$800,000 |
Project Location - City |
Cambridge |
| Award Date |
07/17/2009 |
Project Location - State |
MA |
| Project Status |
More than 50% Completed |
Project Location - Zip |
02138-3846
|
| Jobs Reported |
2.13 |
Congressional District |
05 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
HARVARD COLLEGE, PRESIDENT & FELLOWS OF |
| Recipient DUNS Number |
082359691
|
| Recipient Address |
1350 MASS AVE STE 600 |
| Recipient City |
CAMBRIDGE |
| Recipient State |
Massachusetts |
| Recipient Zip |
02138-3846 |
| Recipient Congressional District |
05 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
CAREER: Physical Aspects of Spindle Self-Organization |
| Project Status |
More than 50% Completed |
| Final Project Report Submitted |
No |
| Project Activities Description |
Colleges, Universities, and Professional Schools |
| Quarterly Activities/Project Description |
Our previous work demonstrated that a simple continue model can quantitatively explain detailed aspects of spindle morphology and dynamics. This work establishes a new, experimentally verified, quantitative, theoretical framework for understanding the spindle. These results are based on studies of unperturbed spindles. We have started to investigate if similar approaches can be used to understand the response of the spindle to biochemical perturbations. Our initial efforts have focused on perturbing the protein MCAK, which is known to modify microtubule polymerization dynamics. Preliminary results show qualitative agreement with the predictions of our previously constructed theory. We are in the process of improving these measurements to investigate if quantitative agreement is obtained. |
| Jobs Created |
2.13 |
| Description of Jobs Created |
Research Assistant in the School of Engineering and Applied Sciences; Post-Doctoral Fellow in Molecular and Cellular Biology; Associate Professor of Applied Physics and of Molecular and Cellular Biology |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
49-0101 |
| Award Information |
| Award Date |
07/17/2009 |
| Award Number |
0847188 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
49 |
| Funding Agency Name |
National Science Foundation |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
49 |
| Awarding Agency Name |
National Science Foundation |
| Amount of Award |
$800,000 |
| Funds Invoiced/Received |
$604,395 |
| Expenditure Amount |
$615,909 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
611310 |
| Activity Description |
Colleges, Universities, and Professional Schools |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$30,335 |
| Number of payments to vendors less than $25,000/award |
157 |
| Total Amount of payments to vendors less than $25,000/award |
$105,745 |
RPI RESEARCH PRECISION INSTRUMENTS INC - Award Number 0847188 - RPI RESEARCH PRECISION INSTRUMENTS INC
| Award Number |
0847188 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
01760-4529 |
| Vendor Name |
RPI RESEARCH PRECISION INSTRUMENTS INC |
| Product and Service Description |
DN535490 |
| Payment Amount |
$30,335 |
| Location Information |
| Latitude, Longitude |
42º 22' 18",
-71º 7' 4" |
| Congressional District |
05 |
| Address 1 |
|
| Address 2 |
|
| City |
Cambridge |
| County |
Middlesex |
| State |
MA |
| Zip |
02138-3846 |
|
 |