Grants - AWARD SUMMARY


MEDICAL UNIVERSITY OF SOUTH CAROLINA


Periodontal disease initiation and progression occurs as a consequence of the host immune inflammatory response to oral pathogens. The purpose of this award is to 1)determine the role of over-expressed MKP-1 on IL-6 and TNFalpha mRNA in vitro, 2)determine the contribution of MKP-1 in ontogeny of inflammatory cytokine production and LPS-induced osteoclastogenesis in primary bone marrow macrophages and 3)determine the impact of MKP-1 in inflammatory bone destruction in vivo using MKP-/- mice. These studies will establish the role of LPS-induced cytokine expression and negative regulation in inflammatory bone loss through selective attenuation of p38 MAPK-induced signaling in periodontal bone destruction.

Clarification of Codes

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AWARD OVERVIEW

AWARD OVERVIEW
Award Number 3R01DE18290-04S2 Funding Agency Department of Health and Human Services
Total Award Amount $99,675 Project Location - City Charleston
Award Date 09/22/2009 Project Location - State SC
Project Status Completed Project Location - Zip 29425-8908
Jobs Reported 0.00 Congressional District 01
Project Location - Country US

Recipient Information (Grants)

Recipient Information (Grants)
Recipient Name MEDICAL UNIVERSITY OF SOUTH CAROLINA
Recipient DUNS Number 183710748
Recipient Address 19 HAGOOD AVE STE 408
Recipient City CHARLESTON
Recipient State South Carolina
Recipient Zip 29425-0001
Recipient Congressional District 01
Recipient Country USA
Required to Report Top 5
Highly Compensated Officials		 No

Projects and Jobs Information

Projects and Jobs Information
Project Title Negative Regulation of Innate Immune Responses through MAPK Phosphatases
Project Status Completed
Final Project Report Submitted Yes
Project Activities Description Musculoskeletal & Connective Tissue Diseases
Quarterly Activities/Project Description As defined in the Award Description field
Jobs Created 0.00
Description of Jobs Created None.


Purchaser Information (Grants)

Purchaser Information
Contracting Office ID Not Reported
Contracting Office Name Not Available
Contracting Office Region Not Available
TAS Major Program 75-0874

Award Information

Award Information
Award Date 09/22/2009
Award Number 3R01DE18290-04S2
Order Number
Award Type Grants
Funding Agency ID 75
Funding Agency Name Department of Health and Human Services
Funding Office Name Not Available
Awarding Agency ID 75
Awarding Agency Name Department of Health and Human Services
Amount of Award $99,675
Funds Invoiced/Received $99,675
Expenditure Amount $99,675
Infrastructure Expenditure Amount $0
Infrastructure Purpose and Rationale Not Reported
Infrastructure Point of Contact Name Not Reported
Infrastructure Point of Contact Email Not Reported
Infrastructure Point of Contact Phone Not Reported
Infrastructure Point of Contact Address Not Reported
Infrastructure Point of Contact City Not Reported
Infrastructure Point of Contact State Not Reported
Infrastructure Point of Contact Zip Not Reported

Product or Service Information (Grants)

Product or Service Information
Primary Activity Code G02.14
Activity Description Musculoskeletal & Connective Tissue Diseases

Sub-Awards Information

Sub-Awards Information
Sub-awards to Organizations 0
Sub-award Amounts to Organizations $0
Sub-Awards to Individuals 0
Sub-Award Amounts to Individuals $0
Number of Sub-awards less than $25,000/award 0
Amount of Sub-awards less than $25,000/award $0
Number of payments to vendors greater than $25,000 1
Total Amount of payments to vendors greater than $25,000/award $99,675
Number of payments to vendors less than $25,000/award 0
Total Amount of payments to vendors less than $25,000/award $0




Vendor Transactions

Miltenyi Biotec, Inc. - Award Number 3R01DE18290-04S2 - Miltenyi Biotec, Inc.

Award Number 3R01DE18290-04S2
Sub-Award Number N/A
Vendor DUNS Number 808605919
Vendor HQ Zip Code + 4 95602-9027
Vendor Name Miltenyi Biotec, Inc.
Product and Service Description MACSQuant Analyzer - benchtop cell analyzer for flow analysis
Payment Amount $99,675



Project Location Detail

Location Information
Latitude, Longitude 32º 47' 7", -79º 56' 47"
Congressional District 01
Address 1 171 Ashley Ave.
Address 2
City Charleston
County Charleston
State SC
Zip 29425-8908
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