PRESIDENT & TRUSTEES OF WILLIAMS COLLEGE
The project goals are to improve the utility of bioinformatics tools and compute how RNA binding is modulated in splicing and other contexts.
Bill contributed to three projects:
(1) an improvement to our BINDIGO algorithm's functionality in which we can account for the expected free energy of any pre-existing secondary structure of the long RNA. We will soon test BINDIGO-MFT's applicability to RNA splicing.
(2) a new tool (RNAbows) to better visualize base pairing probabilities of Partition Function calculations and to see the effects that mutations can cause at a glance.
(3) a new algorithm (NESTOR) to identify related structural classes of folds which splits the states at the largest free energy barrier.