SEATTLE CHILDREN'S HOSPITAL
Comparative Effectivenss Research in Pediatric Rheumatic Diseases: Leveraging CA -- The study of childhood rheumatic conditions has been challenged by disease heterogeneity, poor understanding of underlying pathophysiology, small sample sizes, and limited resources. Development of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) has created the opportunities multi-center retrospective and prospective studies of high impact. The initiatives described below will develop the platform for comparative effectiveness research, creating the evidence base for better care, which will translate into reduced health care costs, enabling American businesses to be more competitive globally. These initiatives will stimulate the American economy through employment of clinical coordinators and other research personnel protecting investigators' time and enable employment of clinical pediatric rheumatologists, both centrally and at peripheral sites. The long-term goal is to improve the health related outcomes of children with rheumatic diseases by entering children into treatment protocols and registries which will enable in and of itself improve care, as well as enable the performance of ongoing comparative effectiveness studies of therapies for Pediatric Rheumatic Diseases. The short- term goal of the current application is to create the platform to perform these studies by leveraging the prior work of CARRA and its unique network structure.
| AWARD OVERVIEW |
| Award Number |
1RC1AR058605-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$994,839 |
Project Location - City |
Seattle |
| Award Date |
09/28/2009 |
Project Location - State |
WA |
| Project Status |
Completed |
Project Location - Zip |
98101-1304
|
| Jobs Reported |
2.31 |
Congressional District |
07 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
SEATTLE CHILDREN'S HOSPITAL |
| Recipient DUNS Number |
048682157
|
| Recipient Address |
4800 SAND POINT WAY NE |
| Recipient City |
SEATTLE |
| Recipient State |
Washington |
| Recipient Zip |
98105-3901 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Comparative Effectivenss Research in Pediatric Rheumatic Diseases: Leveraging CA |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Pediatrics Research |
| Quarterly Activities/Project Description |
This proposal will develop robust data elements that will support sustainable pediatric rheumatology comparative effectiveness studies. Data elements will inform the following domains and will allow varying levels of data collection (demographics, core disease features, treatment, co-morbidities, laboratory and radiology usage and data, serious adverse events, patient reported outcomes and important medical events). Development of this rich resource will enable analysis of various treatments to determine which were most effective and safe, and drive future iterations of the protocols. In this application we propose to 1) to develop the platform for studies of comparative effectiveness utilizing data collected from existing registries, ongoing clinical trials and newly developed treatment protocols and 2) develop best care protocols based on currently available literature, experience of CARRA practitioners and consensus techniques. With completion of the project CARRA will be able to: 1) Perform comparative effectiveness research to define optimal care in Pediatric Rheumatic Diseases (PRD), 2) Conduct research that will translate to prevention, better treatment, and cure of PRD, 3) Investigate methods to improve quality of life in children with PRD, 4) Promote a culture where ultimately all children with PRD will be able to participate in research protocols. With 95% of members working at academic centers, knowledge gained from research investigations will be rapidly disseminated and translated into practice. |
| Jobs Created |
2.31 |
| Description of Jobs Created |
.15 FTE PI
.2 FTE PI
.16 FTE Medical Doctor
2 PIs at 0.1 FTE each (me and Norm Ilowite)
4 module leaders at 0.15 FTE each ( Kimura, Von Scheven, Reed, Fuhlbrigge)
3 module consultants at 0.15 FTE each (Morgan-DeWitt, Brunner, Li)
1 overall grant consultant at 0.05 FTE ( Solomon)
1 program manager at 0.5 FTE (Audrey Hendrickson)
|
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0903 |
| Award Information |
| Award Date |
09/28/2009 |
| Award Number |
1RC1AR058605-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$994,839 |
| Funds Invoiced/Received |
$663,411 |
| Expenditure Amount |
$760,920 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H98 - NTEE |
| Activity Description |
Pediatrics Research |
| Sub-Awards Information |
| Sub-awards to Organizations |
5 |
| Sub-award Amounts to Organizations |
$525,301 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
30 |
| Total Amount of payments to vendors less than $25,000/award |
$200,995 |
Sub-award 10110 - BRIGHAM AND WOMEN'S HOSPITAL, INC., THE
| Sub-Award Amount |
$138,372 |
| Sub-Award Date |
02/09/2010 |
| Sub-Awards Disbursed |
$90,047.91 |
| Project Location - City |
Boston |
| Project Location - State |
MA |
| Project Location - Zip Code |
02115-6110 |
| Project Location - Congressional District |
08 |
| Sub-Recipient DUNS Number |
030811269
|
| Sub-Recipient Address |
75 FRANCIS ST |
| Sub-Recipient City |
BOSTON |
| Sub-Recipient State |
Massachusetts |
| Sub-Recipient Zip Code |
02115-6110 |
| Sub-Recipient Congressional District |
08 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 10107 - HACKENSACK UNIVERSITY MEDICAL CENTER
| Sub-Award Amount |
$127,026 |
| Sub-Award Date |
01/11/2010 |
| Sub-Awards Disbursed |
$125,730.68 |
| Project Location - City |
Hackensack |
| Project Location - State |
NJ |
| Project Location - Zip Code |
07601-1901 |
| Project Location - Congressional District |
09 |
| Sub-Recipient DUNS Number |
042797571
|
| Sub-Recipient Address |
30 PROSPECT AVE |
| Sub-Recipient City |
HACKENSACK |
| Sub-Recipient State |
New Jersey |
| Sub-Recipient Zip Code |
07601-1914 |
| Sub-Recipient Congressional District |
09 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 20214 - MAYO CLINIC
| Sub-Award Amount |
$111,454 |
| Sub-Award Date |
07/09/2010 |
| Sub-Awards Disbursed |
$85,663.63 |
| Project Location - City |
Rochester |
| Project Location - State |
MN |
| Project Location - Zip Code |
55905-0001 |
| Project Location - Congressional District |
01 |
| Sub-Recipient DUNS Number |
006471700
|
| Sub-Recipient Address |
200 1ST ST SW |
| Sub-Recipient City |
ROCHESTER |
| Sub-Recipient State |
Minnesota |
| Sub-Recipient Zip Code |
55905-0002 |
| Sub-Recipient Congressional District |
01 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 10105 - MONTEFIORE MEDICAL CENTER
| Sub-Award Amount |
$37,904 |
| Sub-Award Date |
05/18/2010 |
| Sub-Awards Disbursed |
$2,500.00 |
| Project Location - City |
Bronx |
| Project Location - State |
NY |
| Project Location - Zip Code |
10467-2490 |
| Project Location - Congressional District |
17 |
| Sub-Recipient DUNS Number |
041581026
|
| Sub-Recipient Address |
111 E 210TH ST |
| Sub-Recipient City |
BRONX |
| Sub-Recipient State |
New York |
| Sub-Recipient Zip Code |
10467-2401 |
| Sub-Recipient Congressional District |
17 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 10106 - UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
| Sub-Award Amount |
$110,545 |
| Sub-Award Date |
01/20/2010 |
| Sub-Awards Disbursed |
$84,442.31 |
| Project Location - City |
San Francisco |
| Project Location - State |
CA |
| Project Location - Zip Code |
94103-4249 |
| Project Location - Congressional District |
08 |
| Sub-Recipient DUNS Number |
094878337
|
| Sub-Recipient Address |
1855 FOLSOM ST STE 425 |
| Sub-Recipient City |
SAN FRANCISCO |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
94103-4249 |
| Sub-Recipient Congressional District |
08 |
Required To Report Top 5
Highly Compensated Officials |
No |
| Location Information |
| Latitude, Longitude |
47º 36' 56",
-122º 20' 3" |
| Congressional District |
07 |
| Address 1 |
1900 Ninth Avenue |
| Address 2 |
|
| City |
Seattle |
| County |
King |
| State |
WA |
| Zip |
98101-1304 |
|
 |