NORTHWESTERN UNIVERSITY
This project will continue work on developing powerful new reactions and strategies for chemical synthesis. The proposed research aims to develop highly useful synthetic methods centered on the use of N-allylhydrazones as readily prepared compounds that can undergo a diverse array of powerful reactions. Specifically, the research will provide inventive reactions and strategies for preparing complex molecules from simple precursors. Hypothesis driven studies to elucidate the mechanism of these new transformations will provide insight into the underlying molecular processes and inform future reaction development. Application of the reactions in the context of target-directed synthesis of bioactive molecules will demonstrate the methods' usefulness and broader impacts.
With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Regan J. Thomson of the Department of Chemistry at Northwestern University. Professor Regan Thomson's research efforts revolve around the development of powerful synthetic transformations, in particular those of N-allylhydrazones. Such chemistry will contribute to our fundamental ability to construct complicated molecular structures from simple building blocks. Successful development of the methodology will have an impact on synthesis in the pharmaceutical industry.
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| AWARD OVERVIEW |
| Award Number |
0845063 |
Funding Agency |
National Science Foundation |
| Total Award Amount |
$550,000 |
Project Location - City |
Evanston |
| Award Date |
07/30/2009 |
Project Location - State |
IL |
| Project Status |
More than 50% Completed |
Project Location - Zip |
60208-1110
|
| Jobs Reported |
0.74 |
Congressional District |
09 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
NORTHWESTERN UNIVERSITY |
| Recipient DUNS Number |
160079455
|
| Recipient Address |
633 CLARK ST EVANSTON |
| Recipient City |
EVANSTON |
| Recipient State |
Illinois |
| Recipient Zip |
60208-0001 |
| Recipient Congressional District |
09 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
CAREER: Unlocking the Synthetic Potential of N-Allylhydrazones |
| Project Status |
More than 50% Completed |
| Final Project Report Submitted |
No |
| Project Activities Description |
Research & Public Policy Analysis |
| Quarterly Activities/Project Description |
We have continued our progress on utilizing hydrazones as powerful intermediates for chemical synthesis. We have now devised a one pot oxidative [3,3]/intermolecular Friedel-Crafts cascade reaction, that has enabled us to prepare six lignin natural products. These molecules are potential leads for the development of new anti-malarial drugs. |
| Jobs Created |
0.74 |
| Description of Jobs Created |
American Recovery and Reinvestment Act funds have significantly aided the research mission of Northwestern University by providing salary and wage compensation for individuals directly involved in ARRA-funded projects, both at Northwestern and at consortium institutions, as well as at the vendor organizations who provide goods and services in support of that mission. Northwestern has employed a standard methodology for determining jobs created or retained, based on revised guidance presented by OMB on 12-18-09 (ref. M-10-08). Jobs are reported in aggregate for the grant, comprised of calculated figures for hourly and salaried employees at Northwestern plus the reported jobs created or retained by subrecipients. The number of Northwestern hourly employees will be calculated as the number of hours charged to the grant during the quarter divided by the standard hours in a full-time schedule for the quarter. The number of Northwestern salaried employees will be calculated based on the salaries charged to the ARRA fund during the quarter. Following is a list of descriptions for jobs created or retained, in whole or in part, by this ARRA funded project:Research Assistant. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
49-0101 |
| Award Information |
| Award Date |
07/30/2009 |
| Award Number |
0845063 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
49 |
| Funding Agency Name |
National Science Foundation |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
49 |
| Awarding Agency Name |
National Science Foundation |
| Amount of Award |
$550,000 |
| Funds Invoiced/Received |
$313,609 |
| Expenditure Amount |
$326,552 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
**K |
| Activity Description |
Research & Public Policy Analysis |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
0 |
| Total Amount of payments to vendors less than $25,000/award |
$0 |
| Location Information |
| Latitude, Longitude |
42º 3' 20",
-87º 40' 28" |
| Congressional District |
09 |
| Address 1 |
633 Clark St |
| Address 2 |
|
| City |
Evanston |
| County |
Cook |
| State |
IL |
| Zip |
60208-1110 |
|
 |