UNIVERSITY OF TEXAS M D ANDERSON
Very little is known about the genetic alterations contributing o the development and progression of oral cancer. Currently, there are no large scale genomic studies addressing these issues, presumably owing to the cost and difficulties associated with such efforts. Yet knowledge of the underlying genetic causes of oral cancer is crucial to the design of targeted therapies and identification of molecular markers that may prove valuable in the prognosis or early detection. The overall objective of this research proposal is to generate a comprehensive database of the genomic alterations in oral cancer. Leveraging the strength of our extensive and well annotated tumor tissue bank at the University of Texas M.D. Anderson Cancer Center and cutting edge technology developed by Baylor College of Medicine's Human Genome Sequencing Center, we will perform somatic mutation analysis on over 6000 cancer-related genes and identify structural abnormalities over the whole genome for 100 cases of squamous cell carcinoma of the oral tongue (SCCOT). This study will generate information regarding genetic alterations present in SCOTT in unprecedented detail, including mutations, copy number alterations and chromosomal translocations. This single project has widespread potential to result in discovery of dozens of novel therapeutic targets for a cancer where the primary treatments are still surgery, chemotherapy and radiation. Moreover, identification of a panel of genes specifically altered in oral cancer is a critical step in developing diagnostic tests for personalized medicine to treat these devastating and often fatal cancers. At the conclusion of this study, SCCOT will be one of the most well characterized tumor types on the genomic level. PUBLIC HEALTH RELEVANCE: Oral cancer affects 300,000 persons worldwide each year, and the overall survival rate is just above 50%. All cancers are genetic diseases and a better understanding of the genetic alterations that cause cancer could be used to design more effective tumor-specific therapies. This study is a comprehensive large-scale examination of all the genetic changes found in tumors derived from patients with oral cancer and the information gained could have a major impact on the way we treat and detect these and other cancers.
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| AWARD OVERVIEW |
| Award Number |
1RC2DE020958-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$2,398,656 |
Project Location - City |
Houston |
| Award Date |
09/25/2009 |
Project Location - State |
TX |
| Project Status |
Completed |
Project Location - Zip |
77030-4009
|
| Jobs Reported |
0.00 |
Congressional District |
09 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF TEXAS M D ANDERSON |
| Recipient DUNS Number |
800772139
|
| Recipient Address |
1515 HOLCOMBE BLVD UNIT 207 |
| Recipient City |
HOUSTON |
| Recipient State |
Texas |
| Recipient Zip |
77030-4009 |
| Recipient Congressional District |
09 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
ARRA: Comprehensive Analysis of Genetic Alterations in Oral Cancer |
| Project Status |
Completed |
| Final Project Report Submitted |
No |
| Project Activities Description |
Voluntary Health Organizations |
| Quarterly Activities/Project Description |
As defined in the Award Description field. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
n/a |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0874 |
| Award Information |
| Award Date |
09/25/2009 |
| Award Number |
1RC2DE020958-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$2,398,656 |
| Funds Invoiced/Received |
$2,366,923 |
| Expenditure Amount |
$2,378,769 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
813212 |
| Activity Description |
Voluntary Health Organizations |
| Sub-Awards Information |
| Sub-awards to Organizations |
1 |
| Sub-award Amounts to Organizations |
$1,385,719 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
214 |
| Total Amount of payments to vendors less than $25,000/award |
$13,742 |
Sub-award 28734/98013848 - BAYLOR COLLEGE OF MEDICINE
| Sub-Award Amount |
$1,385,719 |
| Sub-Award Date |
11/03/2009 |
| Sub-Awards Disbursed |
$1,385,719.00 |
| Project Location - City |
Houston |
| Project Location - State |
TX |
| Project Location - Zip Code |
77030-3411 |
| Project Location - Congressional District |
09 |
| Sub-Recipient DUNS Number |
051113330
|
| Sub-Recipient Address |
ONE BAYLOR PLAZA T100 |
| Sub-Recipient City |
HOUSTON |
| Sub-Recipient State |
Texas |
| Sub-Recipient Zip Code |
77030-3498 |
| Sub-Recipient Congressional District |
09 |
Required To Report Top 5
Highly Compensated Officials |
No |
| Location Information |
| Latitude, Longitude |
29º 42' 22",
-95º 23' 49" |
| Congressional District |
09 |
| Address 1 |
1515 Holcombe Blvd |
| Address 2 |
|
| City |
Houston |
| County |
Harris |
| State |
TX |
| Zip |
77030-4009 |
|
 |