GEORGETOWN UNIVERSITY (THE)
Dengue viruses (DENV), members of mosquito-borne flaviruses of Flaviviridae family, are included in the NIAID Category A Priority Pathogen as they cause frequent epidemics and serious illness with considerable morbidity and mortality. Two-thirds of human populations live in areas at risk from dengue virus infections. There is no vaccine or antiviral therapeutics currently available for human use.
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| AWARD OVERVIEW |
| Award Number |
1U01AI082068-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$1,188,851 |
Project Location - City |
Washington |
| Award Date |
09/17/2009 |
Project Location - State |
DC |
| Project Status |
Completed |
Project Location - Zip |
20057-1789
|
| Jobs Reported |
0.00 |
Congressional District |
01 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
GEORGETOWN UNIVERSITY (THE) |
| Recipient DUNS Number |
049515844
|
| Recipient Address |
37TH & O STS NW |
| Recipient City |
WASHINGTON |
| Recipient State |
District of Columbia |
| Recipient Zip |
20057-0001 |
| Recipient Congressional District |
01 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Development of Antiviral Therapeutics for Dengue: Inhibitors of Viral Protease |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Research Institutes & Public Policy Analysis |
| Quarterly Activities/Project Description |
▲ The completion of toxicity and cell culture based potency assays of selected high potency
compounds will be pursued in the next quarter.
Aim 1.1. First part, virtual screening for identification of DENV protease inhibitors by Dr. David
Ostrov has been completed and the leads will be validated in the next quarter (Padmanabhan
and Ostrov)
▲ At the Wichita State University supported by sub award, progress related to (a) the
optimization of two novel series of compounds based on the 1, 2-benzisothiazolinone and
isoindolin-1-one scaffolds led to submission of the following manuscript already published
(Groutas and Padmanabhan).
▲ Several manuscripts are in either preparation or has been submitted for publication and are
at different stages of review process as detailed below.
● Srinivasan, P., Boonyasuppaya, S., Saperstein, S., Nagarajan, K., and Padmanabhan, R.
Evaluation of compounds of 8-hydroxyquinoline scaffold as inhibitors dengue virus protease by
in vitro and cell-based replication assays (in preparation) (Padmanabhan?s lab).
● A manuscript entitled, ?Inhibitors of Dengue Virus and West Nile Virus Proteases Based on
the Aminobenzamide Scaffold by Sridhar Aravapalli,
a
Huiguo Lai,
b
Tadahisa Teramoto,
b
Kevin
R. Alliston,
a
Gerald H. Lushington,
c
Eron Ferguson,
a
R. Padmanabhan,
b
William C. Groutas
a*
submitted early in the last quarter was peer-reviewed, revised and resubmitted in this quarter
and is now accepted and published in Bioorg. Med. Chem 20, 4140-4148, 2012.
● A new manuscript has been submitted for publication entitled, ?Design, Synthesis and
Characterization of Novel 1,2-Benzisothiazol-3(2H)-one and 1,3,4-Oxadiazole Hybrid
Derivatives: Potent Inhibitors of Dengue and West Nile Virus Proteases? |
| Jobs Created |
0.00 |
| Description of Jobs Created |
None |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0900 |
| Award Information |
| Award Date |
09/17/2009 |
| Award Number |
1U01AI082068-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$1,188,851 |
| Funds Invoiced/Received |
$1,188,851 |
| Expenditure Amount |
$1,188,851 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
U05 - NTEE |
| Activity Description |
Research Institutes & Public Policy Analysis |
| Sub-Awards Information |
| Sub-awards to Organizations |
3 |
| Sub-award Amounts to Organizations |
$560,000 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
206 |
| Total Amount of payments to vendors less than $25,000/award |
$20,402 |
Sub-award 00069566 - UNIVERSITY OF FLORIDA
| Sub-Award Amount |
$200,000 |
| Sub-Award Date |
12/07/2009 |
| Sub-Awards Disbursed |
$199,897.26 |
| Project Location - City |
Gainesfille |
| Project Location - State |
FL |
| Project Location - Zip Code |
32611-0000 |
| Project Location - Congressional District |
03 |
| Sub-Recipient DUNS Number |
969663814
|
| Sub-Recipient Address |
207 GRINTER HALL |
| Sub-Recipient City |
GAINESVILLE |
| Sub-Recipient State |
Florida |
| Sub-Recipient Zip Code |
32611-5500 |
| Sub-Recipient Congressional District |
03 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award UNI0061602 - UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.
| Sub-Award Amount |
$120,000 |
| Sub-Award Date |
11/20/2009 |
| Sub-Awards Disbursed |
$120,000.00 |
| Project Location - City |
Lawrence |
| Project Location - State |
KS |
| Project Location - Zip Code |
66045-7568 |
| Project Location - Congressional District |
02 |
| Sub-Recipient DUNS Number |
076248616
|
| Sub-Recipient Address |
2385 IRVING HILL RD |
| Sub-Recipient City |
LAWRENCE |
| Sub-Recipient State |
Kansas |
| Sub-Recipient Zip Code |
66045-7563 |
| Sub-Recipient Congressional District |
02 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award R50504-R80060 - WICHITA STATE UNIVERSITY
| Sub-Award Amount |
$240,000 |
| Sub-Award Date |
11/23/2009 |
| Sub-Awards Disbursed |
$239,555.89 |
| Project Location - City |
Witicha |
| Project Location - State |
KS |
| Project Location - Zip Code |
67260-0007 |
| Project Location - Congressional District |
04 |
| Sub-Recipient DUNS Number |
053078127
|
| Sub-Recipient Address |
1845 FAIRMOUNT ST |
| Sub-Recipient City |
WICHITA |
| Sub-Recipient State |
Kansas |
| Sub-Recipient Zip Code |
67260-0001 |
| Sub-Recipient Congressional District |
04 |
Required To Report Top 5
Highly Compensated Officials |
No |
| Location Information |
| Latitude, Longitude |
38º 54' 21",
-77º 3' 40" |
| Congressional District |
01 |
| Address 1 |
|
| Address 2 |
|
| City |
Washington |
| County |
District of Columbia |
| State |
DC |
| Zip |
20057-1789 |
|
 |