HARVARD COLLEGE, PRESIDENT & FELLOWS OF
This is a Competitive Revision of R01DA017792-10, ?Anxiolytic Effects and Abuse of BZ Receptor Ligands?. The overall goal of the parent grant is to investigate the extent to which GABAA (a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA) receptor subtypes are differentially involved in the anxiolytic effects, self-administration, and physical dependence associated with benzodiazepine (BZ) ligands, using relevant nonhuman primate models. The revised component of this application is to evaluate potential sex differences and menstrual cycle effects in BZ self-administration. In patient populations, women are associated with higher rates of BZ use and abuse, which we hypothesize to involve, in part, enhanced reinforcing effects of these ligands by sex hormones and their neuroactive steroid metabolites. Under the parent grant, reinforcing effects are evaluated using progressive-ratio schedules of i.v. drug self-administration, and we are requesting a revision to include experiments with both female and male monkeys. Identification of potential sex differences and menstrual cycle effects on the self-administration of BZ ligands will provide fundamental information for understanding gender-related differences in the abuse potential of these drugs that, in turn, should aid in developing safer and more broadly effective anti-anxiety medications.
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| AWARD OVERVIEW |
| Award Number |
3R01DA011792-11S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$347,000 |
Project Location - City |
Southborough |
| Award Date |
09/21/2009 |
Project Location - State |
MA |
| Project Status |
Completed |
Project Location - Zip |
01772-1346
|
| Jobs Reported |
0.00 |
Congressional District |
03 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
HARVARD COLLEGE, PRESIDENT & FELLOWS OF |
| Recipient DUNS Number |
047006379
|
| Recipient Address |
25 SHATTUCK ST |
| Recipient City |
BOSTON |
| Recipient State |
Massachusetts |
| Recipient Zip |
02115-6027 |
| Recipient Congressional District |
08 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Anxiolytic Effects and Abuse of BZ Receptor Ligands |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Colleges, Universities, and Professional Schools |
| Quarterly Activities/Project Description |
Our focus has been on evaluating BZ self-administration across the menstrual cycle. The shift in focus was necessitated due to budget constraints, and these experiments are the most essential in terms of testing our overall hypothesis that sex differences are determined, in part, due to differences in circulating neuroactive steroid levels. We have completed a rigorous characterization of progesterone and estradiol (E2) levels in plasma across the menstrual cycle in four rhesus monkeys. These animals have been trained in awake blood sampling and vaginal swabs, and by sampling daily between menstruations (determined by positive vaginal swabs), we have extensive records of the progesterone surge that characterizes the luteal phase?the part of the cycle in which neuroactive steroids should be highest in CNS. The animals are now trained to self-administer the BZ midazolam under our progressive ratio schedule. We are using this information for an additional submission as an investigator-initiated R21 or R01. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
There are no jobs to report this quarter. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0908 |
| Award Information |
| Award Date |
09/21/2009 |
| Award Number |
3R01DA011792-11S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$347,000 |
| Funds Invoiced/Received |
$347,000 |
| Expenditure Amount |
$347,000 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
611310 |
| Activity Description |
Colleges, Universities, and Professional Schools |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
11 |
| Total Amount of payments to vendors less than $25,000/award |
$12,624 |
| Location Information |
| Latitude, Longitude |
42º 19' 39",
-71º 30' 2" |
| Congressional District |
03 |
| Address 1 |
|
| Address 2 |
|
| City |
Southborough |
| County |
Worcester |
| State |
MA |
| Zip |
01772-1346 |
|
 |