UNIVERSITY OF ALABAMA AT BIRMINGHAM
This study integrates three research programs and unique sources of female genital specimens to investigate the mucosal and systemic immune processes that impact the acquisition and progression of HIV-1 infection in women.
Choose a quarter and click "Go."
| AWARD OVERVIEW |
| Award Number |
1P01AI083027-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$3,982,810 |
Project Location - City |
BIRMINGHAM |
| Award Date |
09/25/2009 |
Project Location - State |
AL |
| Project Status |
Completed |
Project Location - Zip |
35294-0001
|
| Jobs Reported |
0.00 |
Congressional District |
07 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
| Recipient DUNS Number |
063690705
|
| Recipient Address |
701 S 20TH STREET |
| Recipient City |
BIRMINGHAM |
| Recipient State |
Alabama |
| Recipient Zip |
35294-0001 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
IMMUNOLOGIC UNIQUENESS OF THE FEMALE GENITAL TRACT IN HIV PATHOGENESIS |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
Project 1
To determine the role of vaginal DCs in HIV-1 entry and dissemination, we established protocols to isolate human vaginal mononuclear cells and construct vaginal explants by adapting our protocols for intestinal cell isolation and explant construction. Project 2
In vitro studies on the effect of medroxyprogesterone acetate (MPA) based contraceptives on immune processes. The effect of MPA, progesterone, and estrogen on the ability of T cells and monocytes/macrophages to produce relevant cytokine responses following stimulation was studied. MPA exerts a highly significant immunosuppressive effect on these cell populations and inhibits production of IFN-gamma, TNF-alpha, and other important cytokines and chemokines following stimulation.
Project 3
We demonstrated that MPG suppresses the production of IFN- and TNF- by purified mucosal mononuclear cells isolated from the vaginal and endocervical mucosa of premenopausal and postmenopausal women. In a separate set of studies we showed that MPG inhibits HIV-1-specific T cell responses as determined by ELISPOT and IFN--production assays to a significantly higher degree than progesterone alone.
Core B
During the first year of this application we have enrolled 15 women and 2 males used as controls the majority of whom were African American (76.5%). From these women we have collected blood, menstrual blood, and vaginal fluid samples. These samples were processed in our Center for AIDS Research sponsored processing and storage facility. Furthermore, the majority of these samples were used by the Mestecky and Hel laboratories to accomplish the aims set forth in projects 2 and 3 of our program. Also obtained were vaginal, uterine, and cervical surgical samples that were used to accomplish the goals of project 1. Any remaining funds may be deobligated.
|
| Jobs Created |
0.00 |
| Description of Jobs Created |
none this quarter |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0900 |
| Award Information |
| Award Date |
09/25/2009 |
| Award Number |
1P01AI083027-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$3,982,810 |
| Funds Invoiced/Received |
$3,982,810 |
| Expenditure Amount |
$3,982,810 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
1 |
| Sub-award Amounts to Organizations |
$122,400 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
768 |
| Total Amount of payments to vendors less than $25,000/award |
$355,284 |
Sub-award 000341581-001 - UNIVERSITY OF CALIFORNIA, IRVINE
| Sub-Award Amount |
$122,400 |
| Sub-Award Date |
04/07/2010 |
| Sub-Awards Disbursed |
$99,659.20 |
| Project Location - City |
Orange |
| Project Location - State |
CA |
| Project Location - Zip Code |
92868-3201 |
| Project Location - Congressional District |
46 |
| Sub-Recipient DUNS Number |
046705849
|
| Sub-Recipient Address |
5171 CALIFORNIA AVE STE 150 |
| Sub-Recipient City |
IRVINE |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
92617-3067 |
| Sub-Recipient Congressional District |
45 |
Required To Report Top 5
Highly Compensated Officials |
No |
| Location Information |
| Latitude, Longitude |
33º 30' 24",
-86º 48' 33" |
| Congressional District |
07 |
| Address 1 |
1530 Third Avenue South |
| Address 2 |
|
| City |
BIRMINGHAM |
| County |
Jefferson |
| State |
AL |
| Zip |
35294-0001 |
|
 |