OREGON HEALTH & SCIENCE UNIVERSITY
Contraceptive failure is the primary cause of unintended pregnancy in the United States. With obesity rates at epidemic proportions, any association between obesity and strategies that prevent undesired pregnancies constitutes a significant public health and economic concern. Evidence from recent epidemiological studies and our preliminary data (sub-therapeutic levels of steroid hormones due to drug clearance and half-life) suggest that obesity reduces oral contraceptive efficacy. Further studies are necessary to investigate whether these obesity related changes can be resolved. Such an understanding is critical to finding a contraceptive strategy with better efficacy for these women. The overall goal of this grant is to test several intervention strategies in order to reverse obesity-related pharmacokinetic differences in an effort to improve contraceptive efficacy for these women. The main hypothesis for this proposal is that increased Body Mass Index (BMI) alters oral contraceptive metabolism in a manner which results in inadequate hypothalamic-pituitary-ovarian axis suppression during oral contraceptive use in obese women. Reproductive-aged, ovulatory women of obese (BMI >30 kg/m2), will be placed on oral contraceptives for 2 months, then randomized into two intervention arms for an additional 2 months. At several key time points, synthetic steroid pharmacokinetics, gonadotropins (LH, FSH) and ovarian hormone levels (estradiol, progesterone), ovarian follicular activity by ultrasound monitoring, and cervical mucus testing will be monitored. PUBLIC HEALTH RELEVANCE: Contraceptive failure is the primary cause of unintended pregnancy in the United States. With obesity rates at epidemic proportions, any association between obesity and strategies that prevent undesired pregnancies constitutes a significant public health and economic concern. Evidence from recent epidemiological studies suggests that obesity increases oral contraceptive failure resulting in unplanned pregnancies. Our preliminary data provide the rationale for testing several intervention strategies to provide greater contraceptive efficacy in obese women.
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| AWARD OVERVIEW |
| Award Number |
1R01HD061582-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$1,099,386 |
Project Location - City |
Portland |
| Award Date |
09/22/2009 |
Project Location - State |
OR |
| Project Status |
Completed |
Project Location - Zip |
97239-3098
|
| Jobs Reported |
0.13 |
Congressional District |
01 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
OREGON HEALTH & SCIENCE UNIVERSITY |
| Recipient DUNS Number |
096997515
|
| Recipient Address |
2525 SOUTHWEST 1ST AVENUE STE 201 |
| Recipient City |
PORTLAND |
| Recipient State |
Oregon |
| Recipient Zip |
97201-4762 |
| Recipient Congressional District |
01 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Improving Contraceptie Effectiveness in Obese Women |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
As defined in the Award Description field. This is the final report for this award. The project is complete, but the research effort did not exhaust all funds awarded. We thank you for your support of this project. |
| Jobs Created |
0.13 |
| Description of Jobs Created |
Assistant Professor |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0840 |
| Award Information |
| Award Date |
09/22/2009 |
| Award Number |
1R01HD061582-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$1,099,386 |
| Funds Invoiced/Received |
$1,099,267 |
| Expenditure Amount |
$1,099,267 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
1 |
| Amount of Sub-awards less than $25,000/award |
$17,168 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$29,079 |
| Number of payments to vendors less than $25,000/award |
106 |
| Total Amount of payments to vendors less than $25,000/award |
$140,455 |
UNIVERSITY OF SOUTHERN CALIFORNIA
- Award Number 1R01HD061582-01 - UNIVERSITY OF SOUTHERN CALIFORNIA
| Award Number |
1R01HD061582-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
90007-2439 |
| Vendor Name |
UNIVERSITY OF SOUTHERN CALIFORNIA
|
| Product and Service Description |
622 each Levonogesetrel/ethinyl estradiol tests |
| Payment Amount |
$29,079 |
| Location Information |
| Latitude, Longitude |
45º 29' 56",
-122º 41' 15" |
| Congressional District |
01 |
| Address 1 |
|
| Address 2 |
|
| City |
Portland |
| County |
Multnomah |
| State |
OR |
| Zip |
97239-3098 |
|
 |