SOUTHERN ILLINOIS UNIVERSITY
Prostate cancer is the second most common form of cancer in American males. Genotoxic agents, such as ionizing radiation, ultraviolet light, and oxidizing compounds that are generated in normal cellular processes, can damage DNA and are a major cause of cancer. Cells respond to these genotoxic stressors by inducing gene expression and mobilizing proteins to induce DNA repair for cell survival or to trigger pathways that lead to cell death thereby eliminating a potentially cancerous cell. Deformed Epidermal Autoregulatory Factor-1 (DEAF-1) is a protein increased in response to genotoxic stressors and can regulate gene expression and may facilitate cell death. The proposed studies model genotoxic stresses that are naturally occurring in cells and produced by chemotherapeutic agents used in treating cancer. We hypothesize that protein modifications of DEAF-1 will regulate its subcellular localization and interaction with protein partners, which will in turn determine the balance between cell survival and cell death. The results of these studies may give mechanistic insights into additional targets for the treatment of prostate and other cancers.
Choose a quarter and click "Go."
| AWARD OVERVIEW |
| Award Number |
1R15CA137556-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$218,250 |
Project Location - City |
Carbondale |
| Award Date |
07/17/2009 |
Project Location - State |
IL |
| Project Status |
Completed |
Project Location - Zip |
62901-2594
|
| Jobs Reported |
0.00 |
Congressional District |
12 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
SOUTHERN ILLINOIS UNIVERSITY |
| Recipient DUNS Number |
939007555
|
| Recipient Address |
4709 WOODY HALL RM C 206 |
| Recipient City |
CARBONDALE |
| Recipient State |
Illinois |
| Recipient Zip |
62901-0000 |
| Recipient Congressional District |
12 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
DEAF-1 Interactions and Protein Modifications in Prostate Cells |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Cancer Research |
| Quarterly Activities/Project Description |
The overall purpose of this project is to investigate the mechanism by which DEAF1 enhances apoptosis in mammalian cells. We hypothesized that DEAF1 interacts with Ku70, p53 and other proteins and contributes to increased apoptosis in stressed cells. We have published the interactions of DEAF1 with the DNA repair protein Ku70: Jensik PJ, Huggenvik JI, Collard MW. (2012) Deformed Epidermal Autoregulatory Factor-1 (DEAF1) Interacts with the Ku70 Subunit of the DNA-Dependent Protein Kinase Complex. PLoS One. 2012;7(3):e33404. Epub 2012 Mar 19. PMID: 22442688. We are in the final stages of preparing a manuscript showing DEAF1 is phosphorylated by CDK5 and GSK3 Mutations in the phosphorylation site did not seem to affect cellular localization, DNA binding, transcription, or apoptosis as we hypothesized. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
Not applicable. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0850 |
| Award Information |
| Award Date |
07/17/2009 |
| Award Number |
1R15CA137556-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$218,250 |
| Funds Invoiced/Received |
$218,249 |
| Expenditure Amount |
$218,249 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H02.04 |
| Activity Description |
Cancer Research |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
334 |
| Total Amount of payments to vendors less than $25,000/award |
$45,386 |
| Location Information |
| Latitude, Longitude |
37º 42' 44",
-89º 13' 4" |
| Congressional District |
12 |
| Address 1 |
Southern Illinois University |
| Address 2 |
Physioloy Life Science III Room 2053 |
| City |
Carbondale |
| County |
Jackson |
| State |
IL |
| Zip |
62901-2594 |
|
 |