TRUSTEES OF BOSTON UNIVERSITY
The goal of this project is to employ embryonic stem (ES) cell and induced pluripotent stem (iPS) cell systems to define the genetic and epigenetic programs of the earliest stages of human development, and to decipher whether identifiable components of these programs differ in iPS cells derived from individuals with the two most common inherited lung diseases: cystic fibrosis (CF) or alpha-1 antitrypsin (AAT)-related emphysema. For this proposal, we have developed a novel excisable reprogramming vector able to generate 'clinical grade' iPS cells free of any residual reprogramming transgenes, and we have employed this vector to derive the first known lung disease-specific iPS cells from an individual with cystic fibrosis. We propose here to derive additional clinical grade iPS cell lines from individuals with CF and AAT-deficiency, in order to test the hypothesis that these cells are able to express the complete genetic developmental programs of early human germ layer specification, but deviate from normalcy only upon differentiation into epithelial lineages known to express the inherited mutations. First, we will define the genetic and epigenetic programs of differentiating endodermal cell lineages at defined stages of early human development, using ES and iPS cell model systems. Next we proposed, to determine whether the genetic programs of these differentiated lineages differ when derived from iPS cells of CF or AAT mutant genotypes in comparison to those derived from normal iPS or ES cells. PUBLIC HEALTH RELEVANCE: Cystic fibrosis and alpha-1 antitrypsin deficiency-related emphysema are the two most common inherited lung diseases. This proposal develops induced pluripotent stem cells from skin biopsies of normal controls as well as individuals with these diseases. These stem cells will be utilized to better understand the genetic programs of cells carrying the mutations responsible for CF and AAT-deficiency and will be employed to develop new in vitro models that will increase an understanding of the biology of these diseases.
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| AWARD OVERVIEW |
| Award Number |
1RC2HL101535-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$2,716,079 |
Project Location - City |
Boston |
| Award Date |
09/25/2009 |
Project Location - State |
MA |
| Project Status |
Completed |
Project Location - Zip |
02118-2307
|
| Jobs Reported |
0.00 |
Congressional District |
08 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
TRUSTEES OF BOSTON UNIVERSITY |
| Recipient DUNS Number |
604483045
|
| Recipient Address |
85 E NEWTON ST M-921 |
| Recipient City |
BOSTON |
| Recipient State |
Massachusetts |
| Recipient Zip |
02118-2436 |
| Recipient Congressional District |
08 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Characterization of Human Hematopoietic Endodermal Progenitors Derived from i |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
As defined in the award description field. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
No jobs created or retained in the quarter |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0871 |
| Award Information |
| Award Date |
09/25/2009 |
| Award Number |
1RC2HL101535-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$2,716,079 |
| Funds Invoiced/Received |
$2,716,079 |
| Expenditure Amount |
$2,716,079 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
N/A |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
4 |
| Sub-award Amounts to Organizations |
$1,106,026 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
1274 |
| Total Amount of payments to vendors less than $25,000/award |
$554,386 |
Sub-award RA207636NGQ - BOSTON MEDICAL CENTER CORPORATION
| Sub-Award Amount |
$337,548 |
| Sub-Award Date |
11/17/2009 |
| Sub-Awards Disbursed |
$337,547.99 |
| Project Location - City |
Boston |
| Project Location - State |
MA |
| Project Location - Zip Code |
02118-2518 |
| Project Location - Congressional District |
08 |
| Sub-Recipient DUNS Number |
005492160
|
| Sub-Recipient Address |
88 EAST NEWTON ST |
| Sub-Recipient City |
BOSTON |
| Sub-Recipient State |
Massachusetts |
| Sub-Recipient Zip Code |
02118-2308 |
| Sub-Recipient Congressional District |
08 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award RA207578NGQ - BOSTON MEDICAL CENTER CORPORATION
| Sub-Award Amount |
$338,000 |
| Sub-Award Date |
11/09/2009 |
| Sub-Awards Disbursed |
$338,000.00 |
| Project Location - City |
Boston |
| Project Location - State |
MA |
| Project Location - Zip Code |
02118-2518 |
| Project Location - Congressional District |
08 |
| Sub-Recipient DUNS Number |
005492160
|
| Sub-Recipient Address |
88 EAST NEWTON ST |
| Sub-Recipient City |
BOSTON |
| Sub-Recipient State |
Massachusetts |
| Sub-Recipient Zip Code |
02118-2308 |
| Sub-Recipient Congressional District |
08 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award RA207682NGQ - CHILDRENS HOSPITAL OF PHILADELPHIA
| Sub-Award Amount |
$329,532 |
| Sub-Award Date |
12/01/2009 |
| Sub-Awards Disbursed |
$329,532.00 |
| Project Location - City |
Philadelphia |
| Project Location - State |
PA |
| Project Location - Zip Code |
19104-4318 |
| Project Location - Congressional District |
02 |
| Sub-Recipient DUNS Number |
073757627
|
| Sub-Recipient Address |
34TH ST CIVIC CTR BLVD |
| Sub-Recipient City |
PHILADELPHIA |
| Sub-Recipient State |
Pennsylvania |
| Sub-Recipient Zip Code |
19104-4318 |
| Sub-Recipient Congressional District |
02 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award RA207757NGQ - UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE
| Sub-Award Amount |
$100,946 |
| Sub-Award Date |
12/17/2009 |
| Sub-Awards Disbursed |
$100,946.00 |
| Project Location - City |
Burlington |
| Project Location - State |
VT |
| Project Location - Zip Code |
05405-1704 |
| Project Location - Congressional District |
00 |
| Sub-Recipient DUNS Number |
066811191
|
| Sub-Recipient Address |
85 S PROSPECT ST |
| Sub-Recipient City |
BURLINGTON |
| Sub-Recipient State |
Vermont |
| Sub-Recipient Zip Code |
05405-1704 |
| Sub-Recipient Congressional District |
00 |
Required To Report Top 5
Highly Compensated Officials |
No |
| Location Information |
| Latitude, Longitude |
42º 20' 11",
-71º 4' 23" |
| Congressional District |
08 |
| Address 1 |
72 East Concord Street |
| Address 2 |
|
| City |
Boston |
| County |
Suffolk |
| State |
MA |
| Zip |
02118-2307 |
|
 |