UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS
During the next two years this project will test the hypothesis that abnormal imprinting of the IGF2 gene is a biomarker for colorectal cancer (CRC) predisposition, which exerts its increase risk via the IGF axis, resulting in specific pathological and molecular characteristics and a unique CRC phenotype. During the next two years of this award the following specific aims will be pursue: 1) To determine whether LOI of IGF2 in lymphocytes is associated with proliferation index, apoptosis index, and micro-vascular density of colorectal cancer; 2) To determine whether LOI of IGF2 in peripheral lymphocytes is associated with rectal cancer recurrence in individuals with Duke?s B/C rectal cancer.
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| AWARD OVERVIEW |
| Award Number |
3K22CA115913-03S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$145,650 |
Project Location - City |
San Juan |
| Award Date |
09/25/2009 |
Project Location - State |
PR |
| Project Status |
Completed |
Project Location - Zip |
00936-5067
|
| Jobs Reported |
0.00 |
Congressional District |
98 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS |
| Recipient DUNS Number |
948108063
|
| Recipient Address |
PUERTO RICO MEDICAL CENTER |
| Recipient City |
SAN JUAN |
| Recipient State |
Puerto Rico |
| Recipient Zip |
00935-5067 |
| Recipient Congressional District |
98 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
CLINICOPATHOLOGY OF IGF2 LOSS OF IMPRINTING IN COLON NEOPLASMA |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Cancer Research |
| Quarterly Activities/Project Description |
We have completed recruitment of colorectal patients as per our sample size calculation. There are three manuscripts in preparation including 1) Association of LOI of IGF2 with non colorectal cancer 2) Evaluation of IGF2 mRNA, tissue IGF2, and serum IGF2 with abnormal imprinting of IGF2 3) Risk of recurrence of colorectal cancer among IGF2 deficient patients. We have completed our first no-cost extension and requested a second no-cost extension to complete analysis by John Hopkins. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
No jobs created or retained for this quarter. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0850 |
| Award Information |
| Award Date |
09/25/2009 |
| Award Number |
3K22CA115913-03S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$145,650 |
| Funds Invoiced/Received |
$145,650 |
| Expenditure Amount |
$145,650 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H02.04 |
| Activity Description |
Cancer Research |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$47,421 |
| Number of payments to vendors less than $25,000/award |
6 |
| Total Amount of payments to vendors less than $25,000/award |
$64,067 |
Bioanalytical Instruments - Award Number 3K22CA115913-03S1 - Bioanalytical Instruments
| Award Number |
3K22CA115913-03S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
00984-1800 |
| Vendor Name |
Bioanalytical Instruments |
| Product and Service Description |
StepOnePlus Real Time PCR System with Laptop, Digital Speedvac systems, Roto for 40 X 1.5 ml Microcentrifuge tube, ULT 706 Upright Freezer.
|
| Payment Amount |
$47,421 |
| Location Information |
| Latitude, Longitude |
18º 25' 3",
-66º 4' 34" |
| Congressional District |
98 |
| Address 1 |
UNIVERSITY OF PUERTO RICO |
| Address 2 |
MEDICAL SCIENCES CAMPUS |
| City |
San Juan |
| County |
San Juan |
| State |
PR |
| Zip |
00936-5067 |
|
 |