MASSACHUSETTS GENERAL HOSPITAL, THE
Bipolar I disorder (BP-I) is a chronic disorder with recurrent depressed and/or manic mood episodes. Recurrent episodes of depression constitute the most functionally debilitating aspect for individuals with bipolar I disorder (BP-I). Mood stabilizers are the first line of treatment for patients with bipolar disorder in a depressive episode. However, these treatments fail to bring sustained remission for most patients. For example, despite the use of mood-stabilizing agents, longitudinal data suggests relapse rates as high as 40% in one year, 60% in two years, and 73% in five or more years. Thus, despite advances in the pharmacologic treatment of bipolar disorder, it has become clear that additional strategies are needed to provide patients with longer-term mood stability. Cognitive-Behavior Therapy (CBT) has been shown to enhance medication compliance as well as to reduce rates of relapses in patients with bipolar disorder. Although there is substantial evidence that CBT is an effective treatment for depressive episodes in major depression, surprisingly few studies have investigated the efficacy of CBT for depressive episodes in bipolar disorder. In addition, existing CBT studies suffer from several short-comings including small sample sizes, the lack of control groups and active control treatments. The present application addresses this gap by proposing to conduct a randomized controlled treatment trial of CBT compared to supportive psychotherapy (the most widely available type of psychotherapy in the community) in depressed patients with bipolar I disorder and to investigate moderators and mediators of treatment response to CBT.
| AWARD OVERVIEW |
| Award Number |
3K23MH074895-03S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$52,486 |
Project Location - City |
Boston |
| Award Date |
07/31/2009 |
Project Location - State |
MA |
| Project Status |
Completed |
Project Location - Zip |
02114-0000
|
| Jobs Reported |
0.00 |
Congressional District |
09 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
MASSACHUSETTS GENERAL HOSPITAL, THE |
| Recipient DUNS Number |
073130411
|
| Recipient Address |
55 FRUIT ST |
| Recipient City |
BOSTON |
| Recipient State |
Massachusetts |
| Recipient Zip |
02114-2621 |
| Recipient Congressional District |
09 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Cognitive-Behavior Therapy for Bipolar Disorder |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
General Medical and Surgical Hospitals |
| Quarterly Activities/Project Description |
As outlined in the Proposal, we have hired Andrew Peckham, B.A. as a research coordinator in the Bipolar Clinic and Research Program, and as described in previous quarterly reports (and approved by NIMH), we divided the activities of the supplement award between two coordinators (now including Amanda Duffy, B.S.), resulting in the creation of another position. Over the course of this study, we reviewed the Partners HealthCare Research Patient Data Registry (RPDR) to identify practice sites and physicians within Partners HealthCare hospitals that treat patients with bipolar disorder. From this inquiry we selected the Mass. General Hospital in Chelsea as an additional site for recruitment and established relationships with this MGH facility. We advertised both at Brigham and Women?s Hospital (Dr. Erb) and Cambridge Hospital (Dr. Kinrys) who served as the point persons at the additional recruitment sites. Both research coordinators funded by this supplement, Mr. Peckham and Ms. Duffy, tracked minority patients in the Bipolar Clinic and Research Program. Overall, these research coordinators have recruited and enrolled two African-American participants and one Asian participant. We are continuing to track African-American participants who are interested in participating in research, as well as continuing to explore options to expand advertising at other sites with large minority populations. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
The purpose of this administrative supplement is (1) to increase the diversity of the sample of patients with DSM-IV bipolar I disorder that is currently being recruited for the ongoing K-Award project and (2) accelerate the speed of scientific research by increasing speed of recruitment of patients. Diversity will be increased in the domains of illness severity of patients DSM-IV bipolar I disorder and ethnic/racial diversity. This will yield a more generalizable sample and increase overall statistical power for moderator analyses thereby facilitating future decisions about personalizing (adapting) treatment for patients with bipolar disorder. Patient recruitment will be speeded up by 6 months compared to the recruitment plan outlined in the parent grant. To accomplish these goals, we will implement new recruitment procedures and hire an additional full-time research coordinator (Andrew Peckham, BA, recent college graduate) whose work will by solely dedicated to support achieving these goals. Scientific Activities of the new research coordinator: Mr. Peckham will engage in the following activities dedicated to broaden and increase recruitment under the guidance of the K-Award PI, Dr. Deckersbach: 1. Utilizing the Partners HealthCare Research Patient Data Registry (RPDR) to identify practice sites and physicians within Partners HealthCare hospitals that treat patients with bipolar disorder. 2. Support the PI in establishing and maintaining relationships with practices identified through the RPDR. This includes: (1) Going to practice meetings and advertising for the studies. (2) Staying in touch with interested physicians. (3) Assisting the PI in giving presentations to groups of physicians/psychologists/social workers. (4) Providing recruitment feedback about patient participation to these practices. (5) Connecting with patient advocacy groups associated with these practices. 3. Support the PI in facilitating minority recruitment through the established collaborations with Dr. Kinrys (Mood and Anxiety Disorder Program Cambridge Hospital), and Dr. Erb (Brigham and Women?s Hospital). Specifically, Dr. Kinrys and Dr. Erb will be asked to identify patients in their programs who are likely to meet inclusion/exclusion criteria for the K-Award project. (1) Mr. Peckham will assist Drs. Kinrys and Erb in tracking these patients and facilitate their referral once these patients become depressed (and hence eligible for the study). (2) We will provide the same service also to all other physicians/psychologists or social workers who are part of Dr. Kinrys? or Erb?s program. (3) Mr. Peckham will assist the PI giving presentations to groups of physicians/psychologists/social workers. (4) Provide recruitment feedback about patient participation to these practices. (5) Connect with patient advocacy groups associated with these practices. In addition, Mr. Peckham will assist with data entry, and ensuring data integrity, as well as the preparation of manuscripts resulting from this project in year 5 (until September 2011).
|
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0907 |
| Award Information |
| Award Date |
07/31/2009 |
| Award Number |
3K23MH074895-03S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$52,486 |
| Funds Invoiced/Received |
$52,486 |
| Expenditure Amount |
$52,486 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
622110 |
| Activity Description |
General Medical and Surgical Hospitals |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
0 |
| Total Amount of payments to vendors less than $25,000/award |
$0 |
| Location Information |
| Latitude, Longitude |
42º 21' 44",
-71º 4' 11" |
| Congressional District |
09 |
| Address 1 |
55 Fruit Street |
| Address 2 |
|
| City |
Boston |
| County |
Suffolk |
| State |
MA |
| Zip |
02114-0000 |
|
 |