UNIVERSITY OF CALIFORNIA, DAVIS
Under the parent grant, we will develop the methods and tools that will profile glycans in human fluids to enable the discovery of markers for diseases. Cancer is a disease known to accompany aberrant glycosylation. Glycoproteins shed by diseased cells will be harvested for their glycan content and profiled to obtain disease markers. This approach represents a new paradigm for disease marker discovery. It will focus primarily on the glycans as disease markers while neglecting, at first, the identity of the associated proteins. This approach will be multi-faceted and primarily glycocentric; it contrasts and complements the proteome-centered approaches currently under extensive investigations. In this process, we will develop a set of mass spectrometry-based tools for clinical glycomics. These tools will be used to observe changes in glycosylation of diseases in two human fluids, sera and tear. The fluids are chosen by the needs of our collaborator in diseases that include ovarian breast cancer and prostate cancer for sera and other dry eye diseases for tear fluids. While disease markers will be the future outcome of these studies, they will not be the only focus of this project. Instead we will also develop the tools that will be used by our collaborators to discover markers for these diseases and lay the foundation for the use of mass spectrometry in clinics for glycomic analyses. The award is expected to stimulate the economy by procuring equipment and enabling the hiring of additional staff with the expertise in bioinformatics and software development.
| AWARD OVERVIEW |
| Award Number |
3R01GM049077-16S2 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$167,511 |
Project Location - City |
Davis |
| Award Date |
09/30/2009 |
Project Location - State |
CA |
| Project Status |
Completed |
Project Location - Zip |
95616-5270
|
| Jobs Reported |
0.00 |
Congressional District |
01 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF CALIFORNIA, DAVIS |
| Recipient DUNS Number |
047120084
|
| Recipient Address |
1850 RESEARCH PARK DR, STE 300 |
| Recipient City |
DAVIS |
| Recipient State |
California |
| Recipient Zip |
95618-6134 |
| Recipient Congressional District |
01 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Subproject for Institution # 09-000170: The development of mass spectrometry for Clinical Glycomics |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Universities |
| Quarterly Activities/Project Description |
Graduate Research Student has been working in: 1) the automation of glycan release and mass spectrometry analysis and 2) the development of bioinformatics tools for automated annotation of spectra. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
Graduate Research Student. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0852 |
| Award Information |
| Award Date |
09/30/2009 |
| Award Number |
3R01GM049077-16S2 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$167,511 |
| Funds Invoiced/Received |
$166,142 |
| Expenditure Amount |
$167,511 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
B43 - NTEE |
| Activity Description |
Universities |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$82,355 |
| Number of payments to vendors less than $25,000/award |
18 |
| Total Amount of payments to vendors less than $25,000/award |
$28,728 |
Agilent Technologies - Award Number 3R01GM049077-16S2 - Agilent Technologies
| Award Number |
3R01GM049077-16S2 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
80155-4026 |
| Vendor Name |
Agilent Technologies |
| Product and Service Description |
S LAB,KIT ORDERED BY JUSTIN SHAFFER FOR HARRIS LAB,SUBSTANCE ORDERED BY ELAINE HOYE FOR HARRIS LAB,ORDER BY ELAINE FOR HARRIS LAB,FOR LAB USE,SPECTRUM MILL 1-CPU SW LICENSE
FOR: JOHN FROEHLICH AND CARLITO LEBRILLA,Capillary Liquid Chromatography system |
| Payment Amount |
$82,355 |
| Location Information |
| Latitude, Longitude |
38º 32' 25",
-121º 44' 58" |
| Congressional District |
01 |
| Address 1 |
One Shields Avenue |
| Address 2 |
|
| City |
Davis |
| County |
Yolo |
| State |
CA |
| Zip |
95616-5270 |
|
 |