UNIVERSITY OF MASSACHUSETTS
Data resulting from our prior and current research, support the suggestion that the elmiric acids (EMA), which are carboxy containing analogs of the endocannabinoid anandamide, are potential anti-inflammatory agents (Burstein et al., 2007). It was observed that several of these EMAs profoundly reversed prostaglandin ratios from a pro inflammatory to an anti-inflammatory state in a cell culture model. This has formed the basis for a hypothesis on the mechanism of action of these compounds; the PG ratio hypothesis. Other possible mechanisms for the in vivo anti inflammatory actions have also been suggested by various experimental observations. Thus the work proposed here will follow the specific aims listed below, focusing on elucidating possible mechanisms for the anti inflammatory actions of the EMAs.
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| AWARD OVERVIEW |
| Award Number |
1R01DA023635-01A2 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$664,155 |
Project Location - City |
Worcester |
| Award Date |
07/16/2009 |
Project Location - State |
MA |
| Project Status |
Completed |
Project Location - Zip |
01655-0002
|
| Jobs Reported |
1.17 |
Congressional District |
03 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF MASSACHUSETTS |
| Recipient DUNS Number |
603847393
|
| Recipient Address |
55 LAKE AVE N |
| Recipient City |
WORCESTER |
| Recipient State |
Massachusetts |
| Recipient Zip |
01655-0002 |
| Recipient Congressional District |
03 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
The Elmiric Acids: Biologically Active Anandamide Analogs. |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
The data obtained under this award indicate that NAgly (N-arachdonoylglycine), a member of the eicosanoid Several N-linked amino acid-linoleic acid conjugates were studied for their potential as anti inflammatory agents. The parent molecule, N-linoleoylglycine was tested in an in vivo model, the mouse peritonitis assay where it showed activity in reducing leukocyte migration at doses as low as 0.3 mg/kg when administered by mouth in safflower oil. Harvested peritoneal cells produced elevated levels of the inflammationresolving eicosanoid 15-deoxy-13,14-PGJ2. These results are similar to those obtained in earlier studies with N-arachidonoylglycine. An in vitro model using mouse macrophage RAW cells was used to evaluate a small group of structural analogs for their ability to stimulate 15-deoxy-13,14-PGJ2 production. The D-alanine derivative was the most active while the D-phenylalanine showed almost no response. A high degree of stereo specificity was observed comparing the D and L alanine isomers; the latter being the less active. It was concluded that linoleic acid conjugates could provide suitable templates in a drug discovery program leading to novel agents for promoting the resolution of chronic inflammation. The final billing will be complete in the next few weeks. |
| Jobs Created |
1.17 |
| Description of Jobs Created |
Professor, 2 Research Associates |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0908 |
| Award Information |
| Award Date |
07/16/2009 |
| Award Number |
1R01DA023635-01A2 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$664,155 |
| Funds Invoiced/Received |
$621,133 |
| Expenditure Amount |
$621,659 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
175 |
| Total Amount of payments to vendors less than $25,000/award |
$86,063 |
| Location Information |
| Latitude, Longitude |
42º 16' 39",
-71º 45' 33" |
| Congressional District |
03 |
| Address 1 |
55 Lake Avenue North |
| Address 2 |
|
| City |
Worcester |
| County |
Worcester |
| State |
MA |
| Zip |
01655-0002 |
|
 |