MASSACHUSETTS GENERAL HOSPITAL, THE
The innate immune system is an evolutionarily ancient and highly conserved first line of host defense against pathogens in plants, fungi, insects and mammals. Innate immunity is essential for early responses to infection and effective immune responses, but is also an important contributor to acute and chronic inflammatory diseases. Furthermore, Innate Immune cells are also essential for development and regeneration. Over the past 10 years, our understanding of innate immunity has increased exponentially and it is now clear that abnormalities in this system underlie many disease processes. Furthermore, the emergence of antibiotic-resistant strains of bacteria, the need to develop novel vaccination strategies for new pandemics and the threat of bioterrorism have emphasized the need to understand the mechanisms by which hosts fight infection. For these reasons, a focused research program in innate immunity is timely, and we believe that Pediatrics at Massachusetts General Hospital (MGH) is ideally placed to deliver this. MGH has many researchers working in Innate Immunity, and a major concentration of researchers is present in the Developmental Immunology Program, in the Department of Pediatrics. Over the past decade, Developmental Immunology has had a strong track record of major advances in the field of Innate Immunity and has trained a number of investigators and developed junior faculty to independence, where they continue to make major contributions to this area. To continue to support the existing momentum in this field, we have initiated a five year strategic plan in Innate Immunity, aiming to create new research groups and develop research infrastructure. Although a faculty search was started in 2008, and resources and long-term support (years 3-5) are committed, recent financial constraints have restricted short-term funding, leaving us unable to move forward with this at the present time and complete our research program. In this grant we are seeking support for the recruitment and development of a new faculty member to build our core program in Innate Immunity research.
| AWARD OVERVIEW |
| Award Number |
1P30GM092431-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$814,150 |
Project Location - City |
Boston |
| Award Date |
09/30/2009 |
Project Location - State |
MA |
| Project Status |
Completed |
Project Location - Zip |
02114-0000
|
| Jobs Reported |
1.75 |
Congressional District |
09 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
MASSACHUSETTS GENERAL HOSPITAL, THE |
| Recipient DUNS Number |
073130411
|
| Recipient Address |
55 FRUIT ST |
| Recipient City |
BOSTON |
| Recipient State |
Massachusetts |
| Recipient Zip |
02114-2621 |
| Recipient Congressional District |
09 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Recruitment of New Faculty in Innate Immunity Research |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
General Medical and Surgical Hospitals |
| Quarterly Activities/Project Description |
The innate immune system is an evolutionarily ancient and highly conserved first line of host defense against pathogens in plants, fungi, insects and mammals. Innate immunity is essential for early responses to infection and effective immune responses, but is also an important contributor to acute and chronic inflammatory diseases. MGH has many researchers working in Innate Immunity, and a major concentration of researchers are present in the Developmental Immunology Program, in the Department of Pediatrics. Over the past decade, Developmental Immunology has had a strong track record of major advances in the field of Innate Immunity and has trained a number of investigators and developed junior faculty to independence, where they continue to make major contributions to this area. To continue to support the existing momentum in this field, we have initiated a five year strategic plan in Innate Immunity, aiming to create new research groups and develop research infrastructure. This Recovery Act funded award was proposed to supported the recruitment and development of a new faculty member, and an attendant laboratory, to build our core program in Innate Immunity research.
Over the course of the funding period this grant has supported the recruitment of a new faculty member in innate immunity. The recruited faculty member investigates the important question of how microbes are sensed in the intestine, using the tractable model organism C. elegans. In work funded by this grant, we have gained greater insights into the fundamental mechanisms of bacterial recognition by the intestinal epithelium, leading to identification of two new signaling pathways involved in this process. Ongoing work will verify the contribution of these pathways to host defense in humans, opening new potential therapeutic pathways in combating infectious disease.
|
| Jobs Created |
1.75 |
| Description of Jobs Created |
In the past quarter this grant has been used to fund Dr Javier Irazoqui as he establishes his research program. The grant has funded Dr Irazoqui (75% effort), a research technician and a postdoctoral fellow, as well as laboratory supplies for research into innate immune mechanisms of pathogen sensing and defense in the nematode worm, C. elegans.
|
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0852 |
| Award Information |
| Award Date |
09/30/2009 |
| Award Number |
1P30GM092431-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$814,150 |
| Funds Invoiced/Received |
$814,150 |
| Expenditure Amount |
$814,150 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
622110 |
| Activity Description |
General Medical and Surgical Hospitals |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
2 |
| Total Amount of payments to vendors greater than $25,000/award |
$71,836 |
| Number of payments to vendors less than $25,000/award |
757 |
| Total Amount of payments to vendors less than $25,000/award |
$112,263 |
Eppendorf North America, Inc. - Award Number 1P30GM092431-01 - Eppendorf North America, Inc.
| Award Number |
1P30GM092431-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
152088142 |
| Vendor HQ Zip Code + 4 |
11590-2826 |
| Vendor Name |
Eppendorf North America, Inc. |
| Product and Service Description |
MCEP REALPLEX 2 SYSTEM W/LAPTOP - INCLUDES EPPENDORF REPEATER PLUS PIPETTE - measures samples and performs analysis with full automation and measure multiple gene expression quantitatively within a short time using a small amount of samples
|
| Payment Amount |
$26,500 |
VWR International, LLC - Award Number 1P30GM092431-01 - VWR International, LLC
| Award Number |
1P30GM092431-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
150982189 |
| Vendor HQ Zip Code + 4 |
19380-5929 |
| Vendor Name |
VWR International, LLC |
| Product and Service Description |
incubator: environmental chamber 29cuft 0C to +60C 120V 60HZ, Evap pan: condensate evap pan 1900031 for 3940 incubator, incubator: environmental chamber 29cft 208-220 V 0-60C RH above AMB to 95% & Extended warranties on incubators 3920 and 3940 |
| Payment Amount |
$45,336 |
| Location Information |
| Latitude, Longitude |
42º 21' 44",
-71º 4' 11" |
| Congressional District |
09 |
| Address 1 |
55 Fruit Street |
| Address 2 |
|
| City |
Boston |
| County |
Suffolk |
| State |
MA |
| Zip |
02114-0000 |
|
 |