FRED HUTCHINSON CANCER RESEARCH CENTER
We will conduct a genome-wide scan on an Illumina 610k platform for colorectal cancer in the following well characterized study populations: The Women's Health Initiative (WHI), the Nurses' Health Study (NHS), the Physician's Health Study, (PHS), and the Health Professionals Follow-Up Study. Once genotyping is completed, we will investigate blinded and unblinded quality controls, clean data using a well-defined protocol and analyze marginal association as well as interaction between genes and environmental factors. We expect our findings to enhance our understanding of the mechanisms underlying colorectal carcinogenesis. In turn, this will lead to improved prevention and treatment strategies.
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| AWARD OVERVIEW |
| Award Number |
3R01CA059045-12S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$4,609,171 |
Project Location - City |
Seattle |
| Award Date |
09/29/2009 |
Project Location - State |
WA |
| Project Status |
Completed |
Project Location - Zip |
98109-1024
|
| Jobs Reported |
0.00 |
Congressional District |
07 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
FRED HUTCHINSON CANCER RESEARCH CENTER |
| Recipient DUNS Number |
078200995
|
| Recipient Address |
1100 FAIRVIEW AVE N J6-300 |
| Recipient City |
SEATTLE |
| Recipient State |
Washington |
| Recipient Zip |
98109-4433 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Genome-Wide Association Study of Nonsynonymous SNOs in Colon Cancer |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research |
| Quarterly Activities/Project Description |
We hired staff scientists, a programmer, a project manager, a program assistant, and statistical research associates. Staff were supported, in part, by the supplement. Due to changes in technology and associated prices, we requested and receivd approval to use Illumina's HumanCytonSNP-12 and OmniExpress platforms instead of the 610K platform and replication, and to genotype additional populations: a multi-center population-based case-control study (MCCCS), the Vitamins and Lifestyle (VITA) study, a French case-control study (French CCS), and the Darmkrebs: Chancen der Verhutung durch Screening (DACHS) study. We selected samples from studies in the project-Women's Health Initiative (WHI); DACHS;MCCCS; VITAL; French CCS; Nurses Health Study (NHS); Health Professionals Follow-up Study (HPFS); and Physicians Health Study (PHS). Samples were pulled, DNA was extracted, and samples were aliquotted, plated, and sent to the Broad Institute for genotyping. Samples were fingerprinted for quality control, re-plated for genotyping, run through a first pass of genotyping, and reviewed for quality control. Samples not passing QC and with remaining DNA were rerun. Genotype data were delivered, and underwent preliminary quality control, imputatuion, and marginal analyses. We ran preliminary gene-gene interaction, gene-environment interaction, and pathway analyses. Funds remain unspent due to decreased laboratory costs for genotyping. Additionally, there were unexpected delays in receiving data. A subset of samples were re-run, as there were unforeseen Illumina reagent errors that were not apparent until quality control and analyses were performed on the full sample set. Tenotyping delays resulted in delays in final analyses. Personnel costs associated with planned analyses will be supported by the parent award.
|
| Jobs Created |
0.00 |
| Description of Jobs Created |
Staff Scientists: These people will involved in all aspects of study design, implementation, analysis and data reporting, and be responsible for day-to-day scientific aspects of this multi-site study Programmer: This person will assist with documentation, coding, and merging of data sets. He will also assist with developing databases to store data and programs to generate analytical data sets from these databases. Project Managers: These people will coordinate biospecimen handling, monitor progress of this multi-site study, and assist the PI with IRB approvals, management of personnel, purchasing, subcontracts and consultant agreements, as well as budgetary administration and grant reporting. Research Coordinator: This person will assist with data harmonization and merging, conference organization, purchasing, travel coordination, and other administrative components of the project. Principal Investigator: The PI will coordinate, oversee, and guide all activities related to this grant, including study design, implementation, conduct, as well as data analysis and reporting of results.Technical Coordinator and WHI Liaison: This person will coordinate sample selection, biospecimen pulls, DNA extraction, and quality controls for the WHI samples. She will also serve as the liaison to the PI and co-investigators. Professor
|
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0850 |
| Award Information |
| Award Date |
09/29/2009 |
| Award Number |
3R01CA059045-12S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$4,609,171 |
| Funds Invoiced/Received |
$4,571,172 |
| Expenditure Amount |
$4,571,172 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H - NTEE |
| Activity Description |
Medical Research |
| Sub-Awards Information |
| Sub-awards to Organizations |
3 |
| Sub-award Amounts to Organizations |
$3,513,623 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$95,035 |
| Number of payments to vendors less than $25,000/award |
20 |
| Total Amount of payments to vendors less than $25,000/award |
$24,721 |
Sub-award 0000678778 - BRIGHAM AND WOMEN'S HOSPITAL, INC., THE
| Sub-Award Amount |
$1,826,624 |
| Sub-Award Date |
09/29/2009 |
| Sub-Awards Disbursed |
$1,812,633.86 |
| Project Location - City |
Boston |
| Project Location - State |
MA |
| Project Location - Zip Code |
02115-6110 |
| Project Location - Congressional District |
08 |
| Sub-Recipient DUNS Number |
030811269
|
| Sub-Recipient Address |
75 FRANCIS ST |
| Sub-Recipient City |
BOSTON |
| Sub-Recipient State |
Massachusetts |
| Sub-Recipient Zip Code |
02115-6110 |
| Sub-Recipient Congressional District |
08 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 0000686966 - BROAD INSTITUTE, INC., THE
| Sub-Award Amount |
$1,490,517 |
| Sub-Award Date |
09/29/2009 |
| Sub-Awards Disbursed |
$1,483,037.44 |
| Project Location - City |
Cambridge |
| Project Location - State |
MA |
| Project Location - Zip Code |
02142-1401 |
| Project Location - Congressional District |
08 |
| Sub-Recipient DUNS Number |
623544785
|
| Sub-Recipient Address |
7 CAMBRIDGE CTR |
| Sub-Recipient City |
CAMBRIDGE |
| Sub-Recipient State |
Massachusetts |
| Sub-Recipient Zip Code |
02142-1401 |
| Sub-Recipient Congressional District |
08 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 0000678787 - UNIVERSITY OF WASHINGTON
| Sub-Award Amount |
$196,482 |
| Sub-Award Date |
09/29/2009 |
| Sub-Awards Disbursed |
$196,445.00 |
| Project Location - City |
Seattle |
| Project Location - State |
WA |
| Project Location - Zip Code |
98195-7630 |
| Project Location - Congressional District |
07 |
| Sub-Recipient DUNS Number |
605799469
|
| Sub-Recipient Address |
4333 BROOKLYN AVE NE |
| Sub-Recipient City |
SEATTLE |
| Sub-Recipient State |
Washington |
| Sub-Recipient Zip Code |
98195-0001 |
| Sub-Recipient Congressional District |
07 |
Required To Report Top 5
Highly Compensated Officials |
No |
- Award Number 3R01CA059045-12S1 -
| Award Number |
3R01CA059045-12S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
735149309 |
| Vendor HQ Zip Code + 4 |
|
| Vendor Name |
|
| Product and Service Description |
computer |
| Payment Amount |
$95,035 |
| Location Information |
| Latitude, Longitude |
47º 37' 43",
-122º 19' 50" |
| Congressional District |
07 |
| Address 1 |
1100 Fairview Ave N |
| Address 2 |
|
| City |
Seattle |
| County |
King |
| State |
WA |
| Zip |
98109-1024 |
|
 |