Grants - AWARD SUMMARY


UNIVERSITY OF MASSACHUSETTS


Insulin Signaling and Metabolic Regulation in Adipocytes:Failure of normal adipocyte function has been proposed to be a key element in the development of insulin resistance and type 2 diabetes related to obesity. We have pursued studies of regulators of adipocyte metabolic function including the Ste20-related kinase Map4K4. Map4k4 appears to be a negative regulator of adipogenesis and adipocyte metabolism in part by downregulation of the transcription factor PPARgamma. These studies have revealed that Map4K4 may be an element in pathways downstream of inflammatory cytokines such as TNFalpha which have been shown to be overproduced in adipose tissue of obese animals and humans. We have recently developed methodology for adipose-tissue specific, shRNA mediated knockdown of Map4K4 in mice. We propose here to employ this model system to test the hypothesis that Map4k4 mediates obesity and inflammation-associated down regulation of adipocyte function in vivo. These funds were awarded for equipment required to accelerate progress of these studies which may provide novel insight into the connection between obesity and type 2 diabetes.

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AWARD OVERVIEW

AWARD OVERVIEW
Award Number 3R01DK030898-26S1 Funding Agency Department of Health and Human Services
Total Award Amount $198,312 Project Location - City Worcester
Award Date 12/14/2009 Project Location - State MA
Project Status Completed Project Location - Zip 01655-0002
Jobs Reported 0.88 Congressional District 03
Project Location - Country US

Recipient Information (Grants)

Recipient Information (Grants)
Recipient Name UNIVERSITY OF MASSACHUSETTS
Recipient DUNS Number 603847393
Recipient Address 55 LAKE AVE N
Recipient City WORCESTER
Recipient State Massachusetts
Recipient Zip 01655-0002
Recipient Congressional District 03
Recipient Country USA
Required to Report Top 5
Highly Compensated Officials		 No

Projects and Jobs Information

Projects and Jobs Information
Project Title ARRA-Insulin Signaling and Metabolic Regulation in Adipocytes
Project Status Completed
Final Project Report Submitted Yes
Project Activities Description Biochemistry, Biophysics & Molecular Biology
Quarterly Activities/Project Description During this quarter we have continued studies of mouse models with tissue-specific ablation Map4k4 gene expression. Detailed metabolic as well as biochemical and morphological studies of these mice have furthered our prior findings of a remarkable phenotype of these mice: normal insulin sensitivity and glucose disposal in the presence of enlargement of the adipose tissue. This is a surprising finding since adipose tissue expansion in obese humans as well as normal mouse models is typically associated with the development of insulin resistance and diabetes. Our efforts have begun to characterize the molecular and physiological basis of this phenotype and point to a significant role of Map4k4 in mediating some of the deleterious effects of diabetes. The funding provided has been particularly useful in providing equipment for streamlining and improving the quality of gene expression data in our studies of these mice. In addition support for employment of a PhD scientist to lead these studies has accelerated the progress of this study.
Jobs Created 0.88
Description of Jobs Created Post Doc Assoc


Purchaser Information (Grants)

Purchaser Information
Contracting Office ID Not Reported
Contracting Office Name Not Available
Contracting Office Region Not Available
TAS Major Program 75-0883

Award Information

Award Information
Award Date 12/14/2009
Award Number 3R01DK030898-26S1
Order Number
Award Type Grants
Funding Agency ID 75
Funding Agency Name Department of Health and Human Services
Funding Office Name Not Available
Awarding Agency ID 75
Awarding Agency Name Department of Health and Human Services
Amount of Award $198,312
Funds Invoiced/Received $198,191
Expenditure Amount $198,312
Infrastructure Expenditure Amount $0
Infrastructure Purpose and Rationale Not Reported
Infrastructure Point of Contact Name Not Reported
Infrastructure Point of Contact Email Not Reported
Infrastructure Point of Contact Phone Not Reported
Infrastructure Point of Contact Address Not Reported
Infrastructure Point of Contact City Not Reported
Infrastructure Point of Contact State Not Reported
Infrastructure Point of Contact Zip Not Reported

Product or Service Information (Grants)

Product or Service Information
Primary Activity Code U02.02
Activity Description Biochemistry, Biophysics & Molecular Biology

Sub-Awards Information

Sub-Awards Information
Sub-awards to Organizations 0
Sub-award Amounts to Organizations $0
Sub-Awards to Individuals 0
Sub-Award Amounts to Individuals $0
Number of Sub-awards less than $25,000/award 0
Amount of Sub-awards less than $25,000/award $0
Number of payments to vendors greater than $25,000 0
Total Amount of payments to vendors greater than $25,000/award $0
Number of payments to vendors less than $25,000/award 62
Total Amount of payments to vendors less than $25,000/award $117,148







Project Location Detail

Location Information
Latitude, Longitude 42º 16' 39", -71º 45' 33"
Congressional District 03
Address 1 55 Lake Avenue North
Address 2
City Worcester
County Worcester
State MA
Zip 01655-0002
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