UNIVERSITY OF MASSACHUSETTS
TLR4 Signaling in alcoholic liver disease, Award Number R01AA017729 from the National Institute On Alcohol Abuse And Alcoholism (NIAAA), is aimed at investigating the role of Toll-like receptor 4-dependent signaling in experimental alcoholic liver disease (ALD). This research proposal will serve the goals of the ARRA at several level. First, it will provide an accelerated path for increasing scientific discovery in a disease (ALD) which affects over 2 million Americans and leads to death of over 20,000 people every year. Second, this proposal will provide secure jobs that otherwise would not be available. Third, by using substantial amounts of laboratory supplies, this project will infuse activity into the economy through purchase or related laboratory supplies.