TRUSTEES OF TUFTS COLLEGE INC
Infection of children with Shiga toxin (Stx) producing Escherichia coli (STEC), primarily a food and waterborne aquired disease, is the leading cause of hemolytic-uremic syndrom (HUS) in the US. There is no specific treatment to prevent or ameliorate HUS. We propose to develop aptamer-based therapeutic agents for prevention or treatment of HUS.
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| AWARD OVERVIEW |
| Award Number |
1U01AI082079-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$1,345,823 |
Project Location - City |
North Grafton |
| Award Date |
09/11/2009 |
Project Location - State |
MA |
| Project Status |
More than 50% Completed |
Project Location - Zip |
01536-1828
|
| Jobs Reported |
1.08 |
Congressional District |
02 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
TRUSTEES OF TUFTS COLLEGE INC |
| Recipient DUNS Number |
039318308
|
| Recipient Address |
136 HARRISON AVE |
| Recipient City |
BOSTON |
| Recipient State |
Massachusetts |
| Recipient Zip |
02111-1817 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Development of Aptamer-based therapy against HUS |
| Project Status |
More than 50% Completed |
| Final Project Report Submitted |
No |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
We generated ssDNA aptamer pool by employing one of the most common methods, asymmetric PCR amplification which produces ssDNA due to the unequal concentration of sense and antisense primers in the reaction mixture. In the past few months, we optimized assymetric PCR by using different ratios of sense and antisense primers (like 1:20, 1:40, 1:80, 1:160) to generate ssDNA efficiently. In addition, we also performed 3 rounds of ssDNA selections with N23 pool using nitrocellulose membrane filtration method. The filter binding assay to estimate the enrichment of the pool with ssDNA and RNA aptamers binding to Stx2 is undergoing. |
| Jobs Created |
1.08 |
| Description of Jobs Created |
Assistant Professor: this individual works in field research study or studies. S/he works independently to participate in or lead a portion of a research project or projects. The researcher contributes ideas and suggestions to the research effort, operates independently and publishes papers in collaboration with the senior investigator. Works with Principal Investigator on data analysis, and writing. Postdoctoral Associate: This individual participates with other University staff in a research project or projects. Postdoctoral Associate/Scholar is considered a training appointment. While the work of the postdoc should be guided by the senior investigator, the person in this position is expected to contribute ideas and suggestions to the research and to publish results. The individual in this position may be given other guided responsibilities such as supervision of staff, grant proposal writing, writing papers, etc. to prepare for an independent scientific career. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0900 |
| Award Information |
| Award Date |
09/11/2009 |
| Award Number |
1U01AI082079-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$1,345,823 |
| Funds Invoiced/Received |
$1,276,202 |
| Expenditure Amount |
$1,277,356 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
1 |
| Sub-award Amounts to Organizations |
$59,382 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
716 |
| Total Amount of payments to vendors less than $25,000/award |
$220,046 |
Sub-award Hyperion Biotechnology Inc - HYPERION BIOTECHNOLOGY INC
| Sub-Award Amount |
$59,382 |
| Sub-Award Date |
10/30/2009 |
| Sub-Awards Disbursed |
$59,381.99 |
| Project Location - City |
San Antonio |
| Project Location - State |
TX |
| Project Location - Zip Code |
78248-1232 |
| Project Location - Congressional District |
21 |
| Sub-Recipient DUNS Number |
063027986
|
| Sub-Recipient Address |
13302 LANGTRY ST |
| Sub-Recipient City |
SAN ANTONIO |
| Sub-Recipient State |
Texas |
| Sub-Recipient Zip Code |
78248-1232 |
| Sub-Recipient Congressional District |
21 |
Required To Report Top 5
Highly Compensated Officials |
No |
| Location Information |
| Latitude, Longitude |
42º 14' 51",
-71º 40' 34" |
| Congressional District |
02 |
| Address 1 |
Tufts University Cummings School of Veterinary Medicine |
| Address 2 |
200 Westboro Road |
| City |
North Grafton |
| County |
Worcester |
| State |
MA |
| Zip |
01536-1828 |
|
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