UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS
During the past quarter, we have made excellent progress in establishing Dr. Anwarul Ferdous as an independent investigator in the Division of Cardiology here at UT Southwestern Medical Center. He is swiftly establishing an independent program of research on the biology of FoxO transcription factors in cardiovascular development and disease. I n addition, he is moving forward with a research program on microRNAs during cardiovascular development. He has hired a new research assistant and purchased the requisite equipment and supplies needed to launch his independent career. All of this is being supported either by the P30 or by institutional resources. The original objectives as laid out in the P30 application are unchanged, and we are presently on pace according to the timelines that we originally proposed.
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| AWARD OVERVIEW |
| Award Number |
1P30HL101254-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$1,287,252 |
Project Location - City |
Dallas |
| Award Date |
09/28/2009 |
Project Location - State |
TX |
| Project Status |
Completed |
Project Location - Zip |
75390-9020
|
| Jobs Reported |
0.00 |
Congressional District |
30 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS |
| Recipient DUNS Number |
800771545
|
| Recipient Address |
5323 HARRY HINES BLVD |
| Recipient City |
DALLAS |
| Recipient State |
Texas |
| Recipient Zip |
75390-7208 |
| Recipient Congressional District |
30 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Functional Genomics of Complex Vascular Disease - ARRA Stimulus New Faculty |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Specialties Research |
| Quarterly Activities/Project Description |
The Total Expenditure is less than the Award Amount. The project was completed under budget. No more funds will be expended.Project#1a:Transcriptional regulation of cardiovascular systems by FoxO1.We completed our initial goal to understand the role of FoxO1 in development.We demonstrated that FoxO1 governs Vcam1 expression, and that FoxO1-Vacam1 axis is intimately involved in cardiovascular as well as placental morphogenesis(Ferdous et al, 2011 and Ferdous and Hill 2012).To define the independent role of FoxO1 in cardiovascular development,we utilized lineage tracing study,which suggests that FoxO1 is involved in valve development/function. Project#1b:Transcriptional regulation of cardiac remodeling by FoxO1.he Ferdous lab is also utilizing a conditional FoxO1 knockout mouse model for myocyte-specific ablation of FoxO1 gene and to investigate its role in cardiac remodeling following pressure overload.We identified that inactivation of FoxO1 blunts pathological hypertrophy.We identified that the FoxO1-thyroid axis participates in pathological remodeling of heart following stress.Project#2:Transcriptional regulation of myogenic differentiation&cardiac fibrosis by Ets-family transcription factors.The genesis of vascular and muscular progenitor cells from a common ancestor is known, yet transcriptional regulation of this alternative cell fate remains elusive.We found that Fli1 acts as a critical node of vascular vs. muscular fate of the progenitor cells.Project#3:Effects of posttranscriptional regulation of connexin 43 expression by micro-RNA on cardiac function and remodeling. Using luciferase plasmid harboring the 3? untranslated region of Cx-43,miR-19a expression plasmid and virus,we demonstrated that forced expression of mir-19a attenuates Cx-43 expression in vitro and in vivo & that attenuation of Cx43 levels affects calcium homeostasis in neonatal rat cardiomyocytes.Project#4:Identification&characterization of ubiquitinated proteins in autophagic cardiomyocytes. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
N/A |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0871 |
| Award Information |
| Award Date |
09/28/2009 |
| Award Number |
1P30HL101254-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$1,287,252 |
| Funds Invoiced/Received |
$1,286,531 |
| Expenditure Amount |
$1,286,531 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H03.07 |
| Activity Description |
Medical Specialties Research |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$52,750 |
| Number of payments to vendors less than $25,000/award |
455 |
| Total Amount of payments to vendors less than $25,000/award |
$252,692 |
LICOR INC - Award Number 1P30HL101254-01 - LICOR INC
| Award Number |
1P30HL101254-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
68501-2651 |
| Vendor Name |
LICOR INC |
| Product and Service Description |
LABORATORY & SCIENTIFIC FURNISHINGS & EQUIPMENT |
| Payment Amount |
$52,750 |
| Location Information |
| Latitude, Longitude |
32º 48' 45",
-96º 50' 18" |
| Congressional District |
30 |
| Address 1 |
5323 Harry Hines |
| Address 2 |
|
| City |
Dallas |
| County |
Dallas |
| State |
TX |
| Zip |
75390-9020 |
|
 |