UNIVERSITY OF MASSACHUSETTS
This research is a feasibility study that is organ specific and is aimed at determining the ability of a dedicated breast computed tomography system (herein, referred to as breast CT system) to visualize lesions. Specifically, this research is to demonstrate that image quality improvements achieved with advanced image processing approaches could improve lesion visualization and provide for better delineation of its margins, using a three-dimensional (3-D) breast imaging system with isotropic voxel size. Improved visualization of lesions and its margins would improve the confidence to determine malignancy and could potentially improve detection. Determination of lesion margins and volume are also helpful for breast conserving surgical planning and for accurate monitoring and early determination of the effectiveness of therapeutic agents and methods. This research involves 150 human subjects (research participants), all women. The specific aims are: (1) Determine if the lesions that are detected by mammography and referred for biopsy, are visible with breast CT; (2) Determine if there is a correlation between CT numbers and malignancy, in particular for soft tissue (solid masses) abnormalities and to determine if image processing techniques improve correlation between CT numbers and malignancy; (3) Determine whether 3-D volumetric image data from a breast CT exam result in better determination of malignancy than mammography as determined by readers and to determine if image processing results in improved confidence to determine malignancy, and; (4) Determine if breast CT allows for volumetric estimates of breast density. In order to achieve the goals of this research, the tasks are: (1) Initial characterization of the breast CT system; (2) Conducting the clinical feasibility study; (3) Implementation and optimization of image processing techniques; (4) Reader study to determine clinically relevant image processing technique(s); (5) Analyzing the correlation between CT numbers and malignancy; (6) Obtaining volumetric estimates of breast glandular fraction and density, and; (7) Conducting a reader study comparing lesion features and malignancy between breast CT and mammography.
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| AWARD OVERVIEW |
| Award Number |
1R21CA134128-01A2 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$722,700 |
Project Location - City |
Worcester |
| Award Date |
07/16/2009 |
Project Location - State |
MA |
| Project Status |
Completed |
Project Location - Zip |
01655-0002
|
| Jobs Reported |
0.02 |
Congressional District |
03 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF MASSACHUSETTS |
| Recipient DUNS Number |
603847393
|
| Recipient Address |
55 LAKE AVE N |
| Recipient City |
WORCESTER |
| Recipient State |
Massachusetts |
| Recipient Zip |
01655-0002 |
| Recipient Congressional District |
03 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Role of 3D Tomography in Breast Cancer |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Radiologic Technology |
| Quarterly Activities/Project Description |
CLINICAL FEASIBILITY STUDY: Accrual of 150 (practically 100% success on the targeted accrual) cases of dedicated breast CT under an IRB approved protocol is now complete and we are working on the image interpretation and data analysis. Patient accrual for the clinical study was conducted at the Highland Hospital of University of Rochester Medical Center in close collaboration with our group at UMass Medical School. This is one of the largest studies (perhaps one of the two) ever conducted on dedicated breast CT. The staging for the reader study is in progress now at the University of Massachusetts Medical School with the imaging workstation ready for final interpretation (observer studies) and data analysis. The reader study involves radiologists specializing in breast imaging takes preparation of the data, particularly the breast CT images to be presented in a form that can be conveniently evaluated by our group of expert radiologists. The entire process of working with the image data, reader study, analysis and preparation for publication is targeted to be completed ov+B92er the next four months. INSIGHT ON RADIATION DOSIMETRY: Although the dose in breast CT is comparable to a diagnostic mammography exam additional dose reduction is obviously very important. Analysis of 150 cases in terms of glandular fraction, skin thickness, radiation dose, and image processing are in progress. We developed a method to determine volumetric estimates of glandular fraction that uses automated segmentation of skin, fibroglandular tissue and adipose tissue. In addition a method to determine skin thickness that is highly relevant for determining radiation dose to the breast has been developed. The accuracy of the developed methods has been determined using breast simulating phantom measurements in a clinical flat-panel cone-beam CT system. The methods have been applied to all clinical cases, and two manuscripts are under various stages of peer-review. Expenditures will b |
| Jobs Created |
0.02 |
| Description of Jobs Created |
Research Engineer |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0850 |
| Award Information |
| Award Date |
07/16/2009 |
| Award Number |
1R21CA134128-01A2 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$722,700 |
| Funds Invoiced/Received |
$719,610 |
| Expenditure Amount |
$719,610 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
E07.07 |
| Activity Description |
Medical Radiologic Technology |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
8 |
| Total Amount of payments to vendors less than $25,000/award |
$13,692 |
| Location Information |
| Latitude, Longitude |
42º 16' 39",
-71º 45' 33" |
| Congressional District |
03 |
| Address 1 |
55 Lake Avenue North |
| Address 2 |
|
| City |
Worcester |
| County |
Worcester |
| State |
MA |
| Zip |
01655-0002 |
|
 |