Grants - AWARD SUMMARY


THE VANDERBILT UNIVERSITY


The purpose of this supplement is to fund equipment infrastructure upgrade to allow uninterrupted progress of proposed study in the parent grant. The goal of this study is to understand how the subcellular localization and activation of WASP is regulated during chemotaxis. We hypothesize that a complex interplay among PCH family proteins, RacC, and WASP leads to polarized trafficking of WASP and ACA, resulting in cell polarity establishment via the polarized organization of actin cytoskeleton and asymmetric distribution of ACA during Dictyostelium chemotaxis. Examinination and tracking of polarized trafficking of WASP- or ACAvesicles along the microtubule via live-cell imaging was proposed in the second aim. Spinning disk technology offers several advantages over conventional laser scanning confocal microscope: a wide dynamic range and high sensitivity; minimal phototoxicity and photobleaching which is critical for long-term observation of living cells; fast acquisition of images. Combining the spinning-disk module and an EMCCD camera would allow us to track vesicle movements with significantly higher fidelity and efficiency, which is critical for the completion of the second aim.

Clarification of Codes

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AWARD OVERVIEW

AWARD OVERVIEW
Award Number 3R01GM068097-06A1S1 Funding Agency Department of Health and Human Services
Total Award Amount $95,263 Project Location - City Nashville
Award Date 01/08/2010 Project Location - State TN
Project Status Completed Project Location - Zip 37203-6876
Jobs Reported 0.00 Congressional District 05
Project Location - Country US

Recipient Information (Grants)

Recipient Information (Grants)
Recipient Name THE VANDERBILT UNIVERSITY
Recipient DUNS Number 004413456
Recipient Address 3319 WEST END AVE STE 800
Recipient City NASHVILLE
Recipient State Tennessee
Recipient Zip 37203-6876
Recipient Congressional District 05
Recipient Country USA
Required to Report Top 5
Highly Compensated Officials		 No

Projects and Jobs Information

Projects and Jobs Information
Project Title Spatial Regulation of Cytoskeleton During Chemotaxis
Project Status Completed
Final Project Report Submitted Yes
Project Activities Description Colleges, Universities, and Professional Schools
Quarterly Activities/Project Description The purpose of this supplement is to fund equipment infrastructure upgrade to allow uninterrupted progress of proposed study in the parent grant. The goal of this study is to understand how the subcellular localization and activation of WASP is regulated during chemotaxis. We hypothesize that a complex interplay among PCH family proteins, RacC, and WASP leads to polarized trafficking of WASP and ACA, resulting in cell polarity establishment via the polarized organization of actin cytoskeleton and asymmetric distribution of ACA during Dictyostelium chemotaxis. Examinination and tracking of polarized trafficking of WASP- or ACAvesicles along the microtubule via live-cell imaging was proposed in the second aim. Spinning disk technology offers several advantages over conventional laser scanning confocal microscope: a wide dynamic range and high sensitivity; minimal phototoxicity and photobleaching which is critical for long-term observation of living cells; fast acquisition of images. Combining the spinning-disk module and an EMCCD camera would allow us to track vesicle movements with significantly higher fidelity and efficiency, which is critical for the completion of the second aim.
Jobs Created 0.00
Description of Jobs Created Not applicable at this time.


Purchaser Information (Grants)

Purchaser Information
Contracting Office ID Not Reported
Contracting Office Name Not Available
Contracting Office Region Not Available
TAS Major Program 75-0852

Award Information

Award Information
Award Date 01/08/2010
Award Number 3R01GM068097-06A1S1
Order Number
Award Type Grants
Funding Agency ID 75
Funding Agency Name Department of Health and Human Services
Funding Office Name Not Available
Awarding Agency ID 75
Awarding Agency Name Department of Health and Human Services
Amount of Award $95,263
Funds Invoiced/Received $95,263
Expenditure Amount $95,263
Infrastructure Expenditure Amount $0
Infrastructure Purpose and Rationale Not Reported
Infrastructure Point of Contact Name Not Reported
Infrastructure Point of Contact Email Not Reported
Infrastructure Point of Contact Phone Not Reported
Infrastructure Point of Contact Address Not Reported
Infrastructure Point of Contact City Not Reported
Infrastructure Point of Contact State Not Reported
Infrastructure Point of Contact Zip Not Reported

Product or Service Information (Grants)

Product or Service Information
Primary Activity Code 611310
Activity Description Colleges, Universities, and Professional Schools

Sub-Awards Information

Sub-Awards Information
Sub-awards to Organizations 0
Sub-award Amounts to Organizations $0
Sub-Awards to Individuals 0
Sub-Award Amounts to Individuals $0
Number of Sub-awards less than $25,000/award 0
Amount of Sub-awards less than $25,000/award $0
Number of payments to vendors greater than $25,000 1
Total Amount of payments to vendors greater than $25,000/award $91,412
Number of payments to vendors less than $25,000/award 1
Total Amount of payments to vendors less than $25,000/award $3,851




Vendor Transactions

BioVision Technologies Inc. - Award Number 3R01GM068097-06A1S1 - BioVision Technologies Inc.

Award Number 3R01GM068097-06A1S1
Sub-Award Number N/A
Vendor DUNS Number Not reported
Vendor HQ Zip Code + 4 19341-1233
Vendor Name BioVision Technologies Inc.
Product and Service Description CSU-22-LLM Diode Spinning Disk
Payment Amount $91,412



Project Location Detail

Location Information
Latitude, Longitude 36º 8' 58", -86º 47' 21"
Congressional District 05
Address 1
Address 2
City Nashville
County Davidson
State TN
Zip 37203-6876
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